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Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
BACKGROUND: Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to eva...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622675/ https://www.ncbi.nlm.nih.gov/pubmed/37927891 http://dx.doi.org/10.1016/j.sleepx.2023.100090 |
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author | Al Oweidat, Khaled Toubasi, Ahmad A. Al-Sayegh, Thuraya N. Sinan, Rima A. Mansour, Sara H. Makhamreh, Hanna K. |
author_facet | Al Oweidat, Khaled Toubasi, Ahmad A. Al-Sayegh, Thuraya N. Sinan, Rima A. Mansour, Sara H. Makhamreh, Hanna K. |
author_sort | Al Oweidat, Khaled |
collection | PubMed |
description | BACKGROUND: Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA. METHODS: Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart. RESULTS: The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter. CONCLUSION: In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle. |
format | Online Article Text |
id | pubmed-10622675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106226752023-11-04 Cardiovascular diseases across OSA phenotypes: A retrospective cohort study Al Oweidat, Khaled Toubasi, Ahmad A. Al-Sayegh, Thuraya N. Sinan, Rima A. Mansour, Sara H. Makhamreh, Hanna K. Sleep Med X Article BACKGROUND: Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA. METHODS: Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart. RESULTS: The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter. CONCLUSION: In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle. Elsevier 2023-10-14 /pmc/articles/PMC10622675/ /pubmed/37927891 http://dx.doi.org/10.1016/j.sleepx.2023.100090 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Al Oweidat, Khaled Toubasi, Ahmad A. Al-Sayegh, Thuraya N. Sinan, Rima A. Mansour, Sara H. Makhamreh, Hanna K. Cardiovascular diseases across OSA phenotypes: A retrospective cohort study |
title | Cardiovascular diseases across OSA phenotypes: A retrospective cohort study |
title_full | Cardiovascular diseases across OSA phenotypes: A retrospective cohort study |
title_fullStr | Cardiovascular diseases across OSA phenotypes: A retrospective cohort study |
title_full_unstemmed | Cardiovascular diseases across OSA phenotypes: A retrospective cohort study |
title_short | Cardiovascular diseases across OSA phenotypes: A retrospective cohort study |
title_sort | cardiovascular diseases across osa phenotypes: a retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622675/ https://www.ncbi.nlm.nih.gov/pubmed/37927891 http://dx.doi.org/10.1016/j.sleepx.2023.100090 |
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