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Cardiovascular diseases across OSA phenotypes: A retrospective cohort study

BACKGROUND: Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to eva...

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Autores principales: Al Oweidat, Khaled, Toubasi, Ahmad A., Al-Sayegh, Thuraya N., Sinan, Rima A., Mansour, Sara H., Makhamreh, Hanna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622675/
https://www.ncbi.nlm.nih.gov/pubmed/37927891
http://dx.doi.org/10.1016/j.sleepx.2023.100090
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author Al Oweidat, Khaled
Toubasi, Ahmad A.
Al-Sayegh, Thuraya N.
Sinan, Rima A.
Mansour, Sara H.
Makhamreh, Hanna K.
author_facet Al Oweidat, Khaled
Toubasi, Ahmad A.
Al-Sayegh, Thuraya N.
Sinan, Rima A.
Mansour, Sara H.
Makhamreh, Hanna K.
author_sort Al Oweidat, Khaled
collection PubMed
description BACKGROUND: Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA. METHODS: Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart. RESULTS: The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter. CONCLUSION: In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle.
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spelling pubmed-106226752023-11-04 Cardiovascular diseases across OSA phenotypes: A retrospective cohort study Al Oweidat, Khaled Toubasi, Ahmad A. Al-Sayegh, Thuraya N. Sinan, Rima A. Mansour, Sara H. Makhamreh, Hanna K. Sleep Med X Article BACKGROUND: Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA. METHODS: Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart. RESULTS: The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter. CONCLUSION: In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle. Elsevier 2023-10-14 /pmc/articles/PMC10622675/ /pubmed/37927891 http://dx.doi.org/10.1016/j.sleepx.2023.100090 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Al Oweidat, Khaled
Toubasi, Ahmad A.
Al-Sayegh, Thuraya N.
Sinan, Rima A.
Mansour, Sara H.
Makhamreh, Hanna K.
Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
title Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
title_full Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
title_fullStr Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
title_full_unstemmed Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
title_short Cardiovascular diseases across OSA phenotypes: A retrospective cohort study
title_sort cardiovascular diseases across osa phenotypes: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622675/
https://www.ncbi.nlm.nih.gov/pubmed/37927891
http://dx.doi.org/10.1016/j.sleepx.2023.100090
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