Cargando…

Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report

INTRODUCTION: We report a case of an adult hematopoietic stem cell donor who developed active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the donation of stem cells, the final transplantation was successfully completed without SARS-CoV-2 transmission. CASE REPORT: W...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xin, Ma, Qiaoling, Pang, Aiming, Yang, Donglin, Liang, Chen, Liu, Qingzhen, Liu, Xin, Zheng, Xiaohui, Jiang, Erlie, Han, Mingzhe, Feng, Sizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622707/
https://www.ncbi.nlm.nih.gov/pubmed/37928818
http://dx.doi.org/10.1016/j.idcr.2023.e01913
Descripción
Sumario:INTRODUCTION: We report a case of an adult hematopoietic stem cell donor who developed active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the donation of stem cells, the final transplantation was successfully completed without SARS-CoV-2 transmission. CASE REPORT: We report on a 34-year-old female diagnosed with acute lymphoblastic leukemia who underwent hemiploid hematopoietic stem cell transplantation (HSCT). Both patient and donor received three doses of inactivated SARS-CoV-2 vaccine before transplantation. PB-HSC was collected by the donor during the process of infection with SARS-CoV-2 (mild), and the patient did not show symptoms related to SARS-CoV-2 after transplantation. Nucleic acid and antigen were negative in regular tests. CONCLUSION: In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor selection.