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Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network

BACKGROUND AND PURPOSE: While the clinical hallmarks of transient global amnesia (TGA) are well defined, its pathophysiological causes are poorly understood. Specifically, risk factors for recurrences are yet to be determined. METHODS: This retrospective study analyzed TGA cases diagnosed and treate...

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Autores principales: Taheri, Shadi, Peters, Nils, Zietz, Annaelle, Abel, Berthold, Hubert, Gordian, Barinka, Filip, Wiestler, Hanni, Kovacic, Irena, Linker, Ralf, Schlachetzki, Felix, Backhaus, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622726/
https://www.ncbi.nlm.nih.gov/pubmed/37455507
http://dx.doi.org/10.3988/jcn.2022.0368
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author Taheri, Shadi
Peters, Nils
Zietz, Annaelle
Abel, Berthold
Hubert, Gordian
Barinka, Filip
Wiestler, Hanni
Kovacic, Irena
Linker, Ralf
Schlachetzki, Felix
Backhaus, Roland
author_facet Taheri, Shadi
Peters, Nils
Zietz, Annaelle
Abel, Berthold
Hubert, Gordian
Barinka, Filip
Wiestler, Hanni
Kovacic, Irena
Linker, Ralf
Schlachetzki, Felix
Backhaus, Roland
author_sort Taheri, Shadi
collection PubMed
description BACKGROUND AND PURPOSE: While the clinical hallmarks of transient global amnesia (TGA) are well defined, its pathophysiological causes are poorly understood. Specifically, risk factors for recurrences are yet to be determined. METHODS: This retrospective study analyzed TGA cases diagnosed and treated within the TEMPiS telestroke network and a university stroke center in Germany. Demographic and clinical data were assessed and characteristics of TGA episodes were recorded, such as season of occurrence, trigger factors, duration, and concomitant symptoms. Follow-up of the potential recurrence of TGA was performed using a standardized questionnaire. RESULTS: Overall 109 patients were included (age 64±8 years [mean±SD], 59.6% female). The most common vascular risk factor was arterial hypertension (60.6%), and other concomitant conditions included migraine (11.9%), hypothyroidism (22.9%), and atrial fibrillation (4.6%). The most frequent concomitant clinical feature accompanying the TGA episode at admission was elevated blood pressure (48.6%). Nineteen patients experienced at least one recurrent TGA episode. Migraine and hypothyroidism were only observed in subjects with a single TGA episode without recurrence (migraine: 14.4% without recurrence vs. none in the recurrence group, p=0.02; hypothyroidism: 27.8% without recurrence vs. none in the recurrence group, p=0.009). In contrast, atrial fibrillation was more common in subjects with TGA recurrence (p<0.001). CONCLUSIONS: Arterial hypertension is prevalent in TGA patients, with elevated blood pressure being the most-frequent concomitant condition. In our cohort, recurrence of TGA occurred in approximately one-fifth of patients. Concomitant conditions such as migraine, hypothyroidism, and atrial fibrillation occurred at different frequencies in the two groups.
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spelling pubmed-106227262023-11-04 Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network Taheri, Shadi Peters, Nils Zietz, Annaelle Abel, Berthold Hubert, Gordian Barinka, Filip Wiestler, Hanni Kovacic, Irena Linker, Ralf Schlachetzki, Felix Backhaus, Roland J Clin Neurol Original Article BACKGROUND AND PURPOSE: While the clinical hallmarks of transient global amnesia (TGA) are well defined, its pathophysiological causes are poorly understood. Specifically, risk factors for recurrences are yet to be determined. METHODS: This retrospective study analyzed TGA cases diagnosed and treated within the TEMPiS telestroke network and a university stroke center in Germany. Demographic and clinical data were assessed and characteristics of TGA episodes were recorded, such as season of occurrence, trigger factors, duration, and concomitant symptoms. Follow-up of the potential recurrence of TGA was performed using a standardized questionnaire. RESULTS: Overall 109 patients were included (age 64±8 years [mean±SD], 59.6% female). The most common vascular risk factor was arterial hypertension (60.6%), and other concomitant conditions included migraine (11.9%), hypothyroidism (22.9%), and atrial fibrillation (4.6%). The most frequent concomitant clinical feature accompanying the TGA episode at admission was elevated blood pressure (48.6%). Nineteen patients experienced at least one recurrent TGA episode. Migraine and hypothyroidism were only observed in subjects with a single TGA episode without recurrence (migraine: 14.4% without recurrence vs. none in the recurrence group, p=0.02; hypothyroidism: 27.8% without recurrence vs. none in the recurrence group, p=0.009). In contrast, atrial fibrillation was more common in subjects with TGA recurrence (p<0.001). CONCLUSIONS: Arterial hypertension is prevalent in TGA patients, with elevated blood pressure being the most-frequent concomitant condition. In our cohort, recurrence of TGA occurred in approximately one-fifth of patients. Concomitant conditions such as migraine, hypothyroidism, and atrial fibrillation occurred at different frequencies in the two groups. Korean Neurological Association 2023-11 2023-06-01 /pmc/articles/PMC10622726/ /pubmed/37455507 http://dx.doi.org/10.3988/jcn.2022.0368 Text en Copyright © 2023 Korean Neurological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Taheri, Shadi
Peters, Nils
Zietz, Annaelle
Abel, Berthold
Hubert, Gordian
Barinka, Filip
Wiestler, Hanni
Kovacic, Irena
Linker, Ralf
Schlachetzki, Felix
Backhaus, Roland
Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network
title Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network
title_full Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network
title_fullStr Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network
title_full_unstemmed Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network
title_short Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network
title_sort clinical course and recurrence in transient global amnesia: a study from the tempis telestroke network
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622726/
https://www.ncbi.nlm.nih.gov/pubmed/37455507
http://dx.doi.org/10.3988/jcn.2022.0368
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