Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection

The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense. In this paper, we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses, leading to the discovery of a new group of catecholate-hydroxama...

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Autores principales: Zhao, Haowen, Ren, Yuhao, Xie, Feng, Dai, Huanqin, Liu, Hongwei, Fu, Chengzhang, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622741/
https://www.ncbi.nlm.nih.gov/pubmed/37927895
http://dx.doi.org/10.1016/j.synbio.2023.09.007
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author Zhao, Haowen
Ren, Yuhao
Xie, Feng
Dai, Huanqin
Liu, Hongwei
Fu, Chengzhang
Müller, Rolf
author_facet Zhao, Haowen
Ren, Yuhao
Xie, Feng
Dai, Huanqin
Liu, Hongwei
Fu, Chengzhang
Müller, Rolf
author_sort Zhao, Haowen
collection PubMed
description The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense. In this paper, we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses, leading to the discovery of a new group of catecholate-hydroxamate siderophores, nobachelins, from Nocardiopsisbaichengensis DSM 44845. Nobachelin biosynthesis genes are conserved in several bacteria from the family Nocardiopsidaceae. Structurally, nobachelins feature fatty-acylated hydroxy-ornithine and a rare chlorinated catecholate group. Intriguingly, nobachelins rescued Caenorhabditiselegans from Pseudomonasaeruginosa-mediated killing.
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spelling pubmed-106227412023-11-04 Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection Zhao, Haowen Ren, Yuhao Xie, Feng Dai, Huanqin Liu, Hongwei Fu, Chengzhang Müller, Rolf Synth Syst Biotechnol Article The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense. In this paper, we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses, leading to the discovery of a new group of catecholate-hydroxamate siderophores, nobachelins, from Nocardiopsisbaichengensis DSM 44845. Nobachelin biosynthesis genes are conserved in several bacteria from the family Nocardiopsidaceae. Structurally, nobachelins feature fatty-acylated hydroxy-ornithine and a rare chlorinated catecholate group. Intriguingly, nobachelins rescued Caenorhabditiselegans from Pseudomonasaeruginosa-mediated killing. KeAi Publishing 2023-09-29 /pmc/articles/PMC10622741/ /pubmed/37927895 http://dx.doi.org/10.1016/j.synbio.2023.09.007 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhao, Haowen
Ren, Yuhao
Xie, Feng
Dai, Huanqin
Liu, Hongwei
Fu, Chengzhang
Müller, Rolf
Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection
title Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection
title_full Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection
title_fullStr Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection
title_full_unstemmed Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection
title_short Nobachelins, new siderophores from Nocardiopsisbaichengensis protecting Caenorhabditiselegans from Pseudomonasaeruginosa infection
title_sort nobachelins, new siderophores from nocardiopsisbaichengensis protecting caenorhabditiselegans from pseudomonasaeruginosa infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622741/
https://www.ncbi.nlm.nih.gov/pubmed/37927895
http://dx.doi.org/10.1016/j.synbio.2023.09.007
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