Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

Exosomes as double-membrane vesicles contain various contents of lipids, proteins, mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance intercellular communication and immunomodulation. Currently, numerous studies found that the components of exosomal proteins, nu...

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Autores principales: Wang, Nan, Yao, Yongliang, Qian, Yingfen, Qiu, Dewen, Cao, Hui, Xiang, Huayuan, Wang, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622749/
https://www.ncbi.nlm.nih.gov/pubmed/37928531
http://dx.doi.org/10.3389/fimmu.2023.1254347
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author Wang, Nan
Yao, Yongliang
Qian, Yingfen
Qiu, Dewen
Cao, Hui
Xiang, Huayuan
Wang, Jianjun
author_facet Wang, Nan
Yao, Yongliang
Qian, Yingfen
Qiu, Dewen
Cao, Hui
Xiang, Huayuan
Wang, Jianjun
author_sort Wang, Nan
collection PubMed
description Exosomes as double-membrane vesicles contain various contents of lipids, proteins, mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance intercellular communication and immunomodulation. Currently, numerous studies found that the components of exosomal proteins, nucleic acids or lipids released from host cells are altered following infection with Mycobacterium tuberculosis. Exosomal contents provide excellent biomarkers for the auxiliary diagnosis, efficacy evaluation, and prognosis of tuberculosis. This study aimed to review the current literatures detailing the functions of exosomes in the procedure of M. tuberculosis infection, and determine the potential values of exosomes as biomarkers to assist in the diagnosis and monitoring of tuberculosis.
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spelling pubmed-106227492023-11-04 Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection Wang, Nan Yao, Yongliang Qian, Yingfen Qiu, Dewen Cao, Hui Xiang, Huayuan Wang, Jianjun Front Immunol Immunology Exosomes as double-membrane vesicles contain various contents of lipids, proteins, mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance intercellular communication and immunomodulation. Currently, numerous studies found that the components of exosomal proteins, nucleic acids or lipids released from host cells are altered following infection with Mycobacterium tuberculosis. Exosomal contents provide excellent biomarkers for the auxiliary diagnosis, efficacy evaluation, and prognosis of tuberculosis. This study aimed to review the current literatures detailing the functions of exosomes in the procedure of M. tuberculosis infection, and determine the potential values of exosomes as biomarkers to assist in the diagnosis and monitoring of tuberculosis. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10622749/ /pubmed/37928531 http://dx.doi.org/10.3389/fimmu.2023.1254347 Text en Copyright © 2023 Wang, Yao, Qian, Qiu, Cao, Xiang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Nan
Yao, Yongliang
Qian, Yingfen
Qiu, Dewen
Cao, Hui
Xiang, Huayuan
Wang, Jianjun
Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection
title Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection
title_full Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection
title_fullStr Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection
title_full_unstemmed Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection
title_short Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection
title_sort cargoes of exosomes function as potential biomarkers for mycobacterium tuberculosis infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622749/
https://www.ncbi.nlm.nih.gov/pubmed/37928531
http://dx.doi.org/10.3389/fimmu.2023.1254347
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