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Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion

STUDY DESIGN: This study adopted a retrospective cohort study design. PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF). OVERVIEW OF LITERATURE: The negative effects of DISH on lumb...

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Autores principales: Hagihara, Shusuke, Ohta, Hideki, Tanaka, Jun, Shiokawa, Teruaki, Kida, Yoshikuni, Iguchi, Yohei, Tatsumi, Masato, Shibata, Ryo, Tahara, Kenichi, Shibata, Tatsuya, Sanada, Kyoichi, Ymamoto, Takuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Spine Surgery 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622827/
https://www.ncbi.nlm.nih.gov/pubmed/37788972
http://dx.doi.org/10.31616/asj.2022.0453
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author Hagihara, Shusuke
Ohta, Hideki
Tanaka, Jun
Shiokawa, Teruaki
Kida, Yoshikuni
Iguchi, Yohei
Tatsumi, Masato
Shibata, Ryo
Tahara, Kenichi
Shibata, Tatsuya
Sanada, Kyoichi
Ymamoto, Takuaki
author_facet Hagihara, Shusuke
Ohta, Hideki
Tanaka, Jun
Shiokawa, Teruaki
Kida, Yoshikuni
Iguchi, Yohei
Tatsumi, Masato
Shibata, Ryo
Tahara, Kenichi
Shibata, Tatsuya
Sanada, Kyoichi
Ymamoto, Takuaki
author_sort Hagihara, Shusuke
collection PubMed
description STUDY DESIGN: This study adopted a retrospective cohort study design. PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF). OVERVIEW OF LITERATURE: The negative effects of DISH on lumbar degenerative diseases have been reported, and DISH may be involved in the onset and severity of lumbar spinal canal stenosis. Patients with DISH have significantly more reoperations after posterior lumbar fusion, including TLIF. However, the effects of DISH on bone fusion after TLIF have not been reported. METHODS: The medical records of patients with intervertebral TLIF from 2012 to 2018 were retrospectively examined. The patients were divided into those with fusion and those with pseudoarthrosis, and the following data were compared: age, sex, DISH, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m(2), and L5/S fixation. Statistical analyses were performed using regression models. RESULTS: In this study, 180 patients (78.6%) had fusion and 49 patients (21.4%) had pseudoarthrosis. The number of patients with DISH was significantly higher in the pseudoarthrosis group than in the fusion group (36.7% and 21.7%, respectively; univariate p=0.031, multivariate p=0.019). No significant differences in age, sex, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m(2), and L5/S fixation were observed between the two groups. The risk factors for bone fusion were statistically analyzed in 57 patients with DISH. DISH with a caudal end below Th11 was an independent risk factor for pseudoarthrosis (univariate p=0.011, multivariate p=0.033). CONCLUSIONS: DISH is an independent risk factor for pseudoarthrosis after one intervertebral TLIF, and DISH with a caudal end below Th11 is associated with a higher risk of pseudoarthrosis than DISH without a caudal end below Th11.
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spelling pubmed-106228272023-11-04 Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion Hagihara, Shusuke Ohta, Hideki Tanaka, Jun Shiokawa, Teruaki Kida, Yoshikuni Iguchi, Yohei Tatsumi, Masato Shibata, Ryo Tahara, Kenichi Shibata, Tatsuya Sanada, Kyoichi Ymamoto, Takuaki Asian Spine J Clinical Study STUDY DESIGN: This study adopted a retrospective cohort study design. PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF). OVERVIEW OF LITERATURE: The negative effects of DISH on lumbar degenerative diseases have been reported, and DISH may be involved in the onset and severity of lumbar spinal canal stenosis. Patients with DISH have significantly more reoperations after posterior lumbar fusion, including TLIF. However, the effects of DISH on bone fusion after TLIF have not been reported. METHODS: The medical records of patients with intervertebral TLIF from 2012 to 2018 were retrospectively examined. The patients were divided into those with fusion and those with pseudoarthrosis, and the following data were compared: age, sex, DISH, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m(2), and L5/S fixation. Statistical analyses were performed using regression models. RESULTS: In this study, 180 patients (78.6%) had fusion and 49 patients (21.4%) had pseudoarthrosis. The number of patients with DISH was significantly higher in the pseudoarthrosis group than in the fusion group (36.7% and 21.7%, respectively; univariate p=0.031, multivariate p=0.019). No significant differences in age, sex, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m(2), and L5/S fixation were observed between the two groups. The risk factors for bone fusion were statistically analyzed in 57 patients with DISH. DISH with a caudal end below Th11 was an independent risk factor for pseudoarthrosis (univariate p=0.011, multivariate p=0.033). CONCLUSIONS: DISH is an independent risk factor for pseudoarthrosis after one intervertebral TLIF, and DISH with a caudal end below Th11 is associated with a higher risk of pseudoarthrosis than DISH without a caudal end below Th11. Korean Society of Spine Surgery 2023-10 2023-10-04 /pmc/articles/PMC10622827/ /pubmed/37788972 http://dx.doi.org/10.31616/asj.2022.0453 Text en Copyright © 2023 by Korean Society of Spine Surgery https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Hagihara, Shusuke
Ohta, Hideki
Tanaka, Jun
Shiokawa, Teruaki
Kida, Yoshikuni
Iguchi, Yohei
Tatsumi, Masato
Shibata, Ryo
Tahara, Kenichi
Shibata, Tatsuya
Sanada, Kyoichi
Ymamoto, Takuaki
Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion
title Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion
title_full Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion
title_fullStr Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion
title_full_unstemmed Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion
title_short Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion
title_sort negative effects of diffuse idiopathic skeletal hyperostosis on bone fusion after transforaminal lumbar interbody fusion
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622827/
https://www.ncbi.nlm.nih.gov/pubmed/37788972
http://dx.doi.org/10.31616/asj.2022.0453
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