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Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism

The enzyme cofactor (R)-lipoic acid plays a critical role in central carbon metabolism due to its catalytic function in the generation of acetyl-CoA, which links glycolysis with the tricarboxylic acid cycle. This cofactor is also essential for the generation of succinyl CoA within the tricarboxylic...

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Detalles Bibliográficos
Autores principales: Watson, Paris R., Stollmaier, Juana Goulart, Christianson, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622836/
https://www.ncbi.nlm.nih.gov/pubmed/37703993
http://dx.doi.org/10.1016/j.jbc.2023.105228