GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR

Family B2 or adhesion G protein–coupled receptors (AGPCRs) are distinguished by variable extracellular regions that contain a modular protease, termed the GPCR autoproteolysis-inducing domain that self-cleaves the receptor into an N-terminal fragment (NTF) and a C-terminal fragment (CTF), or seven t...

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Detalles Bibliográficos
Autores principales: Bernadyn, Tyler F., Vizurraga, Alexander, Adhikari, Rashmi, Kwarcinski, Frank, Tall, Gregory G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622838/
https://www.ncbi.nlm.nih.gov/pubmed/37673336
http://dx.doi.org/10.1016/j.jbc.2023.105223

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