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Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis

The sugar, 2,3-diacetamido-2,3-dideoxy-d-mannuronic acid, was first identified ∼40 years ago in the O-antigen of Pseudomonas aeruginosa O:3,a,d. Since then, it has been observed on the O-antigens of various pathogenic Gram-negative bacteria including Bordetella pertussis, Escherichia albertii, and P...

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Detalles Bibliográficos
Autores principales:	Thoden, James B., McKnight, James O., Kroft, Charles W., Jast, Joshua D.T., Holden, Hazel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622841/ https://www.ncbi.nlm.nih.gov/pubmed/37660908 http://dx.doi.org/10.1016/j.jbc.2023.105200

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