Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering

α-synuclein (α-Syn) is a presynaptic protein that is involved in Parkinson’s and other neurodegenerative diseases and binds to negatively charged phospholipids. Previously, we reported that α-Syn clusters synthetic proteoliposomes that mimic synaptic vesicles. This vesicle-clustering activity depend...

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Detalles Bibliográficos
Autores principales: Lai, Ying, Zhao, Chunyu, Tian, Zhiqi, Wang, Chuchu, Fan, Jiaqi, Hu, Xiao, Tu, Jia, Li, Tihui, Leitz, Jeremy, Pfuetzner, Richard A., Liu, Zhengtao, Zhang, Shengnan, Su, Zhaoming, Burré, Jacqueline, Li, Dan, Südhof , Thomas C., Zhu, Zheng-Jiang, Liu, Cong, Brunger, Axel T., Diao, Jiajie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622907/
https://www.ncbi.nlm.nih.gov/pubmed/37883437
http://dx.doi.org/10.1073/pnas.2310174120

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