Cargando…
CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 o...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622983/ https://www.ncbi.nlm.nih.gov/pubmed/37928427 http://dx.doi.org/10.7150/jca.87983 |
_version_ | 1785130656179683328 |
---|---|
author | Wu, Zhiqiang Deng, Liyuan Tao, Jin Lu, Yuhai Zeng, Xiaofei Jia, Weikun Chen, Hu |
author_facet | Wu, Zhiqiang Deng, Liyuan Tao, Jin Lu, Yuhai Zeng, Xiaofei Jia, Weikun Chen, Hu |
author_sort | Wu, Zhiqiang |
collection | PubMed |
description | Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is frequently increased in human lung cancer. Survival analysis indicated that CCT8 expression is closely correlated with inferior overall survival in lung adenocarcinoma (LUAD), but not in lung squamous carcinoma (LUSC). Subsequently, ectopic expression of CCT8 facilitated cell migration and tumor metastasis, and vice versa. Mechanistically, CCT8 interacted and activated ATK. Inhibition of AKT suppressed CCT8-induced cell migration and tumor metastasis. Our findings support CCT8 as a biomarker for LUAD prognosis and as a target for LUAD therapy. |
format | Online Article Text |
id | pubmed-10622983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-106229832023-11-04 CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas Wu, Zhiqiang Deng, Liyuan Tao, Jin Lu, Yuhai Zeng, Xiaofei Jia, Weikun Chen, Hu J Cancer Research Paper Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is frequently increased in human lung cancer. Survival analysis indicated that CCT8 expression is closely correlated with inferior overall survival in lung adenocarcinoma (LUAD), but not in lung squamous carcinoma (LUSC). Subsequently, ectopic expression of CCT8 facilitated cell migration and tumor metastasis, and vice versa. Mechanistically, CCT8 interacted and activated ATK. Inhibition of AKT suppressed CCT8-induced cell migration and tumor metastasis. Our findings support CCT8 as a biomarker for LUAD prognosis and as a target for LUAD therapy. Ivyspring International Publisher 2023-10-02 /pmc/articles/PMC10622983/ /pubmed/37928427 http://dx.doi.org/10.7150/jca.87983 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Wu, Zhiqiang Deng, Liyuan Tao, Jin Lu, Yuhai Zeng, Xiaofei Jia, Weikun Chen, Hu CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
title | CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
title_full | CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
title_fullStr | CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
title_full_unstemmed | CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
title_short | CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
title_sort | cct8 promotes cell migration and tumor metastasis in lung adenocarcinomas |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622983/ https://www.ncbi.nlm.nih.gov/pubmed/37928427 http://dx.doi.org/10.7150/jca.87983 |
work_keys_str_mv | AT wuzhiqiang cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas AT dengliyuan cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas AT taojin cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas AT luyuhai cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas AT zengxiaofei cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas AT jiaweikun cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas AT chenhu cct8promotescellmigrationandtumormetastasisinlungadenocarcinomas |