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CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas

Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 o...

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Detalles Bibliográficos
Autores principales: Wu, Zhiqiang, Deng, Liyuan, Tao, Jin, Lu, Yuhai, Zeng, Xiaofei, Jia, Weikun, Chen, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622983/
https://www.ncbi.nlm.nih.gov/pubmed/37928427
http://dx.doi.org/10.7150/jca.87983
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author Wu, Zhiqiang
Deng, Liyuan
Tao, Jin
Lu, Yuhai
Zeng, Xiaofei
Jia, Weikun
Chen, Hu
author_facet Wu, Zhiqiang
Deng, Liyuan
Tao, Jin
Lu, Yuhai
Zeng, Xiaofei
Jia, Weikun
Chen, Hu
author_sort Wu, Zhiqiang
collection PubMed
description Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is frequently increased in human lung cancer. Survival analysis indicated that CCT8 expression is closely correlated with inferior overall survival in lung adenocarcinoma (LUAD), but not in lung squamous carcinoma (LUSC). Subsequently, ectopic expression of CCT8 facilitated cell migration and tumor metastasis, and vice versa. Mechanistically, CCT8 interacted and activated ATK. Inhibition of AKT suppressed CCT8-induced cell migration and tumor metastasis. Our findings support CCT8 as a biomarker for LUAD prognosis and as a target for LUAD therapy.
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spelling pubmed-106229832023-11-04 CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas Wu, Zhiqiang Deng, Liyuan Tao, Jin Lu, Yuhai Zeng, Xiaofei Jia, Weikun Chen, Hu J Cancer Research Paper Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is frequently increased in human lung cancer. Survival analysis indicated that CCT8 expression is closely correlated with inferior overall survival in lung adenocarcinoma (LUAD), but not in lung squamous carcinoma (LUSC). Subsequently, ectopic expression of CCT8 facilitated cell migration and tumor metastasis, and vice versa. Mechanistically, CCT8 interacted and activated ATK. Inhibition of AKT suppressed CCT8-induced cell migration and tumor metastasis. Our findings support CCT8 as a biomarker for LUAD prognosis and as a target for LUAD therapy. Ivyspring International Publisher 2023-10-02 /pmc/articles/PMC10622983/ /pubmed/37928427 http://dx.doi.org/10.7150/jca.87983 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wu, Zhiqiang
Deng, Liyuan
Tao, Jin
Lu, Yuhai
Zeng, Xiaofei
Jia, Weikun
Chen, Hu
CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
title CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
title_full CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
title_fullStr CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
title_full_unstemmed CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
title_short CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas
title_sort cct8 promotes cell migration and tumor metastasis in lung adenocarcinomas
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622983/
https://www.ncbi.nlm.nih.gov/pubmed/37928427
http://dx.doi.org/10.7150/jca.87983
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