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High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma

Background: The incidence of lung cancer is increasing annually, but the mechanism of its occurrence and development requires further study. This study aimed to investigate the biological function and prognostic value of proline- and serine-rich coiled-coil 1 (PSRC1) in lung cancer. Methods: We used...

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Autores principales: Han, Rui, Guan, Youhong, Tang, Min, Li, Min, Zhang, Binbin, Fei, Guanghe, Zhou, Sijing, Wang, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622992/
https://www.ncbi.nlm.nih.gov/pubmed/37928428
http://dx.doi.org/10.7150/jca.88635
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author Han, Rui
Guan, Youhong
Tang, Min
Li, Min
Zhang, Binbin
Fei, Guanghe
Zhou, Sijing
Wang, Ran
author_facet Han, Rui
Guan, Youhong
Tang, Min
Li, Min
Zhang, Binbin
Fei, Guanghe
Zhou, Sijing
Wang, Ran
author_sort Han, Rui
collection PubMed
description Background: The incidence of lung cancer is increasing annually, but the mechanism of its occurrence and development requires further study. This study aimed to investigate the biological function and prognostic value of proline- and serine-rich coiled-coil 1 (PSRC1) in lung cancer. Methods: We used data from The Cancer Genome Atlas (TCGA) to analyze the association between clinical features and PSRC1 expression in non-small cell carcinoma. The relationship between PSRC1 expression and prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) was analyzed using Kaplan-Meier curves. The function of PSRC1 was identified using enrichment analysis, and the relationship between PSRC1 expression and immune cell infiltration was studied. In addition, the expression of PSRC1 in 150 patients with non-small cell carcinoma was detected using immunohistochemistry, and its clinical significance was analyzed. Results: It was found that the expression level of PSRC1 was higher in LUAD and LUSC tumor tissues than in normal tissues, and the results were confirmed by immunohistochemistry in 150 patients. TCGA data showed that high PSRC1 expression in LUAD was associated with poorer overall survival (p = 0.003) and progression-free interval (p = 0.012). Multivariable analysis showed that PSRC1 was an independent risk factor for LUAD. Functional enrichment analysis showed that PSRC1 is related to tumor development. Conclusion: High PSRC1 expression is significantly associated with LUAD survival and may be a promising prognostic biomarker.
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spelling pubmed-106229922023-11-04 High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma Han, Rui Guan, Youhong Tang, Min Li, Min Zhang, Binbin Fei, Guanghe Zhou, Sijing Wang, Ran J Cancer Research Paper Background: The incidence of lung cancer is increasing annually, but the mechanism of its occurrence and development requires further study. This study aimed to investigate the biological function and prognostic value of proline- and serine-rich coiled-coil 1 (PSRC1) in lung cancer. Methods: We used data from The Cancer Genome Atlas (TCGA) to analyze the association between clinical features and PSRC1 expression in non-small cell carcinoma. The relationship between PSRC1 expression and prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) was analyzed using Kaplan-Meier curves. The function of PSRC1 was identified using enrichment analysis, and the relationship between PSRC1 expression and immune cell infiltration was studied. In addition, the expression of PSRC1 in 150 patients with non-small cell carcinoma was detected using immunohistochemistry, and its clinical significance was analyzed. Results: It was found that the expression level of PSRC1 was higher in LUAD and LUSC tumor tissues than in normal tissues, and the results were confirmed by immunohistochemistry in 150 patients. TCGA data showed that high PSRC1 expression in LUAD was associated with poorer overall survival (p = 0.003) and progression-free interval (p = 0.012). Multivariable analysis showed that PSRC1 was an independent risk factor for LUAD. Functional enrichment analysis showed that PSRC1 is related to tumor development. Conclusion: High PSRC1 expression is significantly associated with LUAD survival and may be a promising prognostic biomarker. Ivyspring International Publisher 2023-10-07 /pmc/articles/PMC10622992/ /pubmed/37928428 http://dx.doi.org/10.7150/jca.88635 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Han, Rui
Guan, Youhong
Tang, Min
Li, Min
Zhang, Binbin
Fei, Guanghe
Zhou, Sijing
Wang, Ran
High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
title High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
title_full High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
title_fullStr High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
title_full_unstemmed High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
title_short High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
title_sort high expression of psrc1 predicts poor prognosis in lung adenocarcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622992/
https://www.ncbi.nlm.nih.gov/pubmed/37928428
http://dx.doi.org/10.7150/jca.88635
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