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High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma
Background: The incidence of lung cancer is increasing annually, but the mechanism of its occurrence and development requires further study. This study aimed to investigate the biological function and prognostic value of proline- and serine-rich coiled-coil 1 (PSRC1) in lung cancer. Methods: We used...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622992/ https://www.ncbi.nlm.nih.gov/pubmed/37928428 http://dx.doi.org/10.7150/jca.88635 |
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author | Han, Rui Guan, Youhong Tang, Min Li, Min Zhang, Binbin Fei, Guanghe Zhou, Sijing Wang, Ran |
author_facet | Han, Rui Guan, Youhong Tang, Min Li, Min Zhang, Binbin Fei, Guanghe Zhou, Sijing Wang, Ran |
author_sort | Han, Rui |
collection | PubMed |
description | Background: The incidence of lung cancer is increasing annually, but the mechanism of its occurrence and development requires further study. This study aimed to investigate the biological function and prognostic value of proline- and serine-rich coiled-coil 1 (PSRC1) in lung cancer. Methods: We used data from The Cancer Genome Atlas (TCGA) to analyze the association between clinical features and PSRC1 expression in non-small cell carcinoma. The relationship between PSRC1 expression and prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) was analyzed using Kaplan-Meier curves. The function of PSRC1 was identified using enrichment analysis, and the relationship between PSRC1 expression and immune cell infiltration was studied. In addition, the expression of PSRC1 in 150 patients with non-small cell carcinoma was detected using immunohistochemistry, and its clinical significance was analyzed. Results: It was found that the expression level of PSRC1 was higher in LUAD and LUSC tumor tissues than in normal tissues, and the results were confirmed by immunohistochemistry in 150 patients. TCGA data showed that high PSRC1 expression in LUAD was associated with poorer overall survival (p = 0.003) and progression-free interval (p = 0.012). Multivariable analysis showed that PSRC1 was an independent risk factor for LUAD. Functional enrichment analysis showed that PSRC1 is related to tumor development. Conclusion: High PSRC1 expression is significantly associated with LUAD survival and may be a promising prognostic biomarker. |
format | Online Article Text |
id | pubmed-10622992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-106229922023-11-04 High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma Han, Rui Guan, Youhong Tang, Min Li, Min Zhang, Binbin Fei, Guanghe Zhou, Sijing Wang, Ran J Cancer Research Paper Background: The incidence of lung cancer is increasing annually, but the mechanism of its occurrence and development requires further study. This study aimed to investigate the biological function and prognostic value of proline- and serine-rich coiled-coil 1 (PSRC1) in lung cancer. Methods: We used data from The Cancer Genome Atlas (TCGA) to analyze the association between clinical features and PSRC1 expression in non-small cell carcinoma. The relationship between PSRC1 expression and prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) was analyzed using Kaplan-Meier curves. The function of PSRC1 was identified using enrichment analysis, and the relationship between PSRC1 expression and immune cell infiltration was studied. In addition, the expression of PSRC1 in 150 patients with non-small cell carcinoma was detected using immunohistochemistry, and its clinical significance was analyzed. Results: It was found that the expression level of PSRC1 was higher in LUAD and LUSC tumor tissues than in normal tissues, and the results were confirmed by immunohistochemistry in 150 patients. TCGA data showed that high PSRC1 expression in LUAD was associated with poorer overall survival (p = 0.003) and progression-free interval (p = 0.012). Multivariable analysis showed that PSRC1 was an independent risk factor for LUAD. Functional enrichment analysis showed that PSRC1 is related to tumor development. Conclusion: High PSRC1 expression is significantly associated with LUAD survival and may be a promising prognostic biomarker. Ivyspring International Publisher 2023-10-07 /pmc/articles/PMC10622992/ /pubmed/37928428 http://dx.doi.org/10.7150/jca.88635 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Han, Rui Guan, Youhong Tang, Min Li, Min Zhang, Binbin Fei, Guanghe Zhou, Sijing Wang, Ran High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma |
title | High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma |
title_full | High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma |
title_fullStr | High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma |
title_full_unstemmed | High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma |
title_short | High Expression of PSRC1 Predicts Poor Prognosis in Lung Adenocarcinoma |
title_sort | high expression of psrc1 predicts poor prognosis in lung adenocarcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622992/ https://www.ncbi.nlm.nih.gov/pubmed/37928428 http://dx.doi.org/10.7150/jca.88635 |
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