Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma

Cholangiocarcinoma (CCA) is the most recurrent malignant tumor found in the biliary system. It originates from the bile duct epithelial cells characterized by easy metastasis, high intermittent rate, and poor prognosis. Acetaldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, the levels...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Bai, Song, Yinghui, Liu, Sulai, Peng, Chuang, Zhang, Yujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622993/
https://www.ncbi.nlm.nih.gov/pubmed/37928420
http://dx.doi.org/10.7150/jca.86967
_version_ 1785130658562048000
author Ding, Bai
Song, Yinghui
Liu, Sulai
Peng, Chuang
Zhang, Yujing
author_facet Ding, Bai
Song, Yinghui
Liu, Sulai
Peng, Chuang
Zhang, Yujing
author_sort Ding, Bai
collection PubMed
description Cholangiocarcinoma (CCA) is the most recurrent malignant tumor found in the biliary system. It originates from the bile duct epithelial cells characterized by easy metastasis, high intermittent rate, and poor prognosis. Acetaldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, the levels of which are particularly elevated in various of malignant tumors. Additionally, the increased ALDH1 levels are closely related to the degree and prognosis of malignant tumors. This study reviewed the mechanisms underlying the changes in ALDH1 levels in CCA.
format Online
Article
Text
id pubmed-10622993
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-106229932023-11-04 Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma Ding, Bai Song, Yinghui Liu, Sulai Peng, Chuang Zhang, Yujing J Cancer Review Cholangiocarcinoma (CCA) is the most recurrent malignant tumor found in the biliary system. It originates from the bile duct epithelial cells characterized by easy metastasis, high intermittent rate, and poor prognosis. Acetaldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, the levels of which are particularly elevated in various of malignant tumors. Additionally, the increased ALDH1 levels are closely related to the degree and prognosis of malignant tumors. This study reviewed the mechanisms underlying the changes in ALDH1 levels in CCA. Ivyspring International Publisher 2023-09-25 /pmc/articles/PMC10622993/ /pubmed/37928420 http://dx.doi.org/10.7150/jca.86967 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Ding, Bai
Song, Yinghui
Liu, Sulai
Peng, Chuang
Zhang, Yujing
Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
title Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
title_full Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
title_fullStr Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
title_full_unstemmed Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
title_short Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
title_sort mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622993/
https://www.ncbi.nlm.nih.gov/pubmed/37928420
http://dx.doi.org/10.7150/jca.86967
work_keys_str_mv AT dingbai mechanismsunderlyingthechangesinacetaldehydedehydrogenase1incholangiocarcinoma
AT songyinghui mechanismsunderlyingthechangesinacetaldehydedehydrogenase1incholangiocarcinoma
AT liusulai mechanismsunderlyingthechangesinacetaldehydedehydrogenase1incholangiocarcinoma
AT pengchuang mechanismsunderlyingthechangesinacetaldehydedehydrogenase1incholangiocarcinoma
AT zhangyujing mechanismsunderlyingthechangesinacetaldehydedehydrogenase1incholangiocarcinoma

Ejemplares similares