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Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles

Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here, we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich microdomains present in phospholipid bilayers. Although the copy number of Munc13-1 molecules in these clusters has a b...

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Detalles Bibliográficos
Autores principales: Li, Feng, Grushin, Kirill, Coleman, Jeff, Pincet, Frederic, Rothman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623011/
https://www.ncbi.nlm.nih.gov/pubmed/37883433
http://dx.doi.org/10.1073/pnas.2306086120

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