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Pyroptosis in host defence against bacterial infection

Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and by the release of cytokines, damage- and pathogen-associated molecular patterns. It plays an important role during bacterial infection, where it can promote an inflammatory response and eliminate the repl...

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Detalles Bibliográficos
Autores principales: Brokatzky, Dominik, Mostowy, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623139/
https://www.ncbi.nlm.nih.gov/pubmed/35801644
http://dx.doi.org/10.1242/dmm.049414
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author Brokatzky, Dominik
Mostowy, Serge
author_facet Brokatzky, Dominik
Mostowy, Serge
author_sort Brokatzky, Dominik
collection PubMed
description Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and by the release of cytokines, damage- and pathogen-associated molecular patterns. It plays an important role during bacterial infection, where it can promote an inflammatory response and eliminate the replicative niche of intracellular pathogens. Recent work, using a variety of bacterial pathogens, has illuminated the versatility of pyroptosis, revealing unexpected and important concepts underlying host defence. In this Review, we overview the molecular mechanisms underlying pyroptosis and discuss their role in host defence, from the single cell to the whole organism. We focus on recent studies using three cellular microbiology paradigms – Mycobacterium tuberculosis, Salmonella Typhimurium and Shigella flexneri – that have transformed the field of pyroptosis. We compare insights discovered in tissue culture, zebrafish and mouse models, highlighting the advantages and disadvantages of using these complementary infection models to investigate pyroptosis and for modelling human infection. Moving forward, we propose that in-depth knowledge of pyroptosis obtained from complementary infection models can better inform future studies using higher vertebrates, including humans, and help develop innovative host-directed therapies to combat bacterial infection.
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spelling pubmed-106231392023-11-04 Pyroptosis in host defence against bacterial infection Brokatzky, Dominik Mostowy, Serge Dis Model Mech Review Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and by the release of cytokines, damage- and pathogen-associated molecular patterns. It plays an important role during bacterial infection, where it can promote an inflammatory response and eliminate the replicative niche of intracellular pathogens. Recent work, using a variety of bacterial pathogens, has illuminated the versatility of pyroptosis, revealing unexpected and important concepts underlying host defence. In this Review, we overview the molecular mechanisms underlying pyroptosis and discuss their role in host defence, from the single cell to the whole organism. We focus on recent studies using three cellular microbiology paradigms – Mycobacterium tuberculosis, Salmonella Typhimurium and Shigella flexneri – that have transformed the field of pyroptosis. We compare insights discovered in tissue culture, zebrafish and mouse models, highlighting the advantages and disadvantages of using these complementary infection models to investigate pyroptosis and for modelling human infection. Moving forward, we propose that in-depth knowledge of pyroptosis obtained from complementary infection models can better inform future studies using higher vertebrates, including humans, and help develop innovative host-directed therapies to combat bacterial infection. The Company of Biologists Ltd 2022-07-08 /pmc/articles/PMC10623139/ /pubmed/35801644 http://dx.doi.org/10.1242/dmm.049414 Text en © 2022. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Brokatzky, Dominik
Mostowy, Serge
Pyroptosis in host defence against bacterial infection
title Pyroptosis in host defence against bacterial infection
title_full Pyroptosis in host defence against bacterial infection
title_fullStr Pyroptosis in host defence against bacterial infection
title_full_unstemmed Pyroptosis in host defence against bacterial infection
title_short Pyroptosis in host defence against bacterial infection
title_sort pyroptosis in host defence against bacterial infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623139/
https://www.ncbi.nlm.nih.gov/pubmed/35801644
http://dx.doi.org/10.1242/dmm.049414
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