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GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns t...

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Autores principales: Dharavath, Ravinder Naik, Pina-Leblanc, Celeste, Tang, Victor M., Sloan, Matthew E., Nikolova, Yuliya S., Pangarov, Peter, Ruocco, Anthony C., Shield, Kevin, Voineskos, Daphne, Blumberger, Daniel M., Boileau, Isabelle, Bozinoff, Nikki, Gerretsen, Philip, Vieira, Erica, Melamed, Osnat C., Sibille, Etienne, Quilty, Lena C., Prevot, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623140/
https://www.ncbi.nlm.nih.gov/pubmed/37929054
http://dx.doi.org/10.3389/fncir.2023.1218737
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author Dharavath, Ravinder Naik
Pina-Leblanc, Celeste
Tang, Victor M.
Sloan, Matthew E.
Nikolova, Yuliya S.
Pangarov, Peter
Ruocco, Anthony C.
Shield, Kevin
Voineskos, Daphne
Blumberger, Daniel M.
Boileau, Isabelle
Bozinoff, Nikki
Gerretsen, Philip
Vieira, Erica
Melamed, Osnat C.
Sibille, Etienne
Quilty, Lena C.
Prevot, Thomas D.
author_facet Dharavath, Ravinder Naik
Pina-Leblanc, Celeste
Tang, Victor M.
Sloan, Matthew E.
Nikolova, Yuliya S.
Pangarov, Peter
Ruocco, Anthony C.
Shield, Kevin
Voineskos, Daphne
Blumberger, Daniel M.
Boileau, Isabelle
Bozinoff, Nikki
Gerretsen, Philip
Vieira, Erica
Melamed, Osnat C.
Sibille, Etienne
Quilty, Lena C.
Prevot, Thomas D.
author_sort Dharavath, Ravinder Naik
collection PubMed
description Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.
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spelling pubmed-106231402023-11-04 GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential Dharavath, Ravinder Naik Pina-Leblanc, Celeste Tang, Victor M. Sloan, Matthew E. Nikolova, Yuliya S. Pangarov, Peter Ruocco, Anthony C. Shield, Kevin Voineskos, Daphne Blumberger, Daniel M. Boileau, Isabelle Bozinoff, Nikki Gerretsen, Philip Vieira, Erica Melamed, Osnat C. Sibille, Etienne Quilty, Lena C. Prevot, Thomas D. Front Neural Circuits Neuroscience Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD. Frontiers Media S.A. 2023-10-20 /pmc/articles/PMC10623140/ /pubmed/37929054 http://dx.doi.org/10.3389/fncir.2023.1218737 Text en Copyright © 2023 Dharavath, Pina-Leblanc, Tang, Sloan, Nikolova, Pangarov, Ruocco, Shield, Voineskos, Blumberger, Boileau, Bozinoff, Gerretsen, Vieira, Melamed, Sibille, Quilty and Prevot. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Dharavath, Ravinder Naik
Pina-Leblanc, Celeste
Tang, Victor M.
Sloan, Matthew E.
Nikolova, Yuliya S.
Pangarov, Peter
Ruocco, Anthony C.
Shield, Kevin
Voineskos, Daphne
Blumberger, Daniel M.
Boileau, Isabelle
Bozinoff, Nikki
Gerretsen, Philip
Vieira, Erica
Melamed, Osnat C.
Sibille, Etienne
Quilty, Lena C.
Prevot, Thomas D.
GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
title GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
title_full GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
title_fullStr GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
title_full_unstemmed GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
title_short GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
title_sort gabaergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623140/
https://www.ncbi.nlm.nih.gov/pubmed/37929054
http://dx.doi.org/10.3389/fncir.2023.1218737
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