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GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns t...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623140/ https://www.ncbi.nlm.nih.gov/pubmed/37929054 http://dx.doi.org/10.3389/fncir.2023.1218737 |
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author | Dharavath, Ravinder Naik Pina-Leblanc, Celeste Tang, Victor M. Sloan, Matthew E. Nikolova, Yuliya S. Pangarov, Peter Ruocco, Anthony C. Shield, Kevin Voineskos, Daphne Blumberger, Daniel M. Boileau, Isabelle Bozinoff, Nikki Gerretsen, Philip Vieira, Erica Melamed, Osnat C. Sibille, Etienne Quilty, Lena C. Prevot, Thomas D. |
author_facet | Dharavath, Ravinder Naik Pina-Leblanc, Celeste Tang, Victor M. Sloan, Matthew E. Nikolova, Yuliya S. Pangarov, Peter Ruocco, Anthony C. Shield, Kevin Voineskos, Daphne Blumberger, Daniel M. Boileau, Isabelle Bozinoff, Nikki Gerretsen, Philip Vieira, Erica Melamed, Osnat C. Sibille, Etienne Quilty, Lena C. Prevot, Thomas D. |
author_sort | Dharavath, Ravinder Naik |
collection | PubMed |
description | Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD. |
format | Online Article Text |
id | pubmed-10623140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106231402023-11-04 GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential Dharavath, Ravinder Naik Pina-Leblanc, Celeste Tang, Victor M. Sloan, Matthew E. Nikolova, Yuliya S. Pangarov, Peter Ruocco, Anthony C. Shield, Kevin Voineskos, Daphne Blumberger, Daniel M. Boileau, Isabelle Bozinoff, Nikki Gerretsen, Philip Vieira, Erica Melamed, Osnat C. Sibille, Etienne Quilty, Lena C. Prevot, Thomas D. Front Neural Circuits Neuroscience Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD. Frontiers Media S.A. 2023-10-20 /pmc/articles/PMC10623140/ /pubmed/37929054 http://dx.doi.org/10.3389/fncir.2023.1218737 Text en Copyright © 2023 Dharavath, Pina-Leblanc, Tang, Sloan, Nikolova, Pangarov, Ruocco, Shield, Voineskos, Blumberger, Boileau, Bozinoff, Gerretsen, Vieira, Melamed, Sibille, Quilty and Prevot. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Dharavath, Ravinder Naik Pina-Leblanc, Celeste Tang, Victor M. Sloan, Matthew E. Nikolova, Yuliya S. Pangarov, Peter Ruocco, Anthony C. Shield, Kevin Voineskos, Daphne Blumberger, Daniel M. Boileau, Isabelle Bozinoff, Nikki Gerretsen, Philip Vieira, Erica Melamed, Osnat C. Sibille, Etienne Quilty, Lena C. Prevot, Thomas D. GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
title | GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
title_full | GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
title_fullStr | GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
title_full_unstemmed | GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
title_short | GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
title_sort | gabaergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623140/ https://www.ncbi.nlm.nih.gov/pubmed/37929054 http://dx.doi.org/10.3389/fncir.2023.1218737 |
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