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Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation

Regular and moderate exercise is being used for therapeutic purposes in treating several diseases, including cancer, cardiovascular diseases, arthritis, and even chronic kidney diseases (CKDs). Conversely, extenuating physical exercise has long been pointed out as one of the sources of acute kidney...

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Autores principales: Costanti-Nascimento, Ana Carolina, Brelaz-Abreu, Leonilia, Bragança-Jardim, Elayne, Pereira, Welbert de Oliveira, Camara, Niels Olsen Saraiva, Amano, Mariane Tami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623152/
https://www.ncbi.nlm.nih.gov/pubmed/37928533
http://dx.doi.org/10.3389/fimmu.2023.1212163
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author Costanti-Nascimento, Ana Carolina
Brelaz-Abreu, Leonilia
Bragança-Jardim, Elayne
Pereira, Welbert de Oliveira
Camara, Niels Olsen Saraiva
Amano, Mariane Tami
author_facet Costanti-Nascimento, Ana Carolina
Brelaz-Abreu, Leonilia
Bragança-Jardim, Elayne
Pereira, Welbert de Oliveira
Camara, Niels Olsen Saraiva
Amano, Mariane Tami
author_sort Costanti-Nascimento, Ana Carolina
collection PubMed
description Regular and moderate exercise is being used for therapeutic purposes in treating several diseases, including cancer, cardiovascular diseases, arthritis, and even chronic kidney diseases (CKDs). Conversely, extenuating physical exercise has long been pointed out as one of the sources of acute kidney injury (AKI) due to its severe impact on the body’s physiology. AKI development is associated with increased tubular necrosis, which initiates a cascade of inflammatory responses. The latter involves cytokine production, immune cell (macrophages, lymphocytes, and neutrophils, among others) activation, and increased oxidative stress. AKI can induce prolonged fibrosis stimulation, leading to CKD development. The need for therapeutic alternative treatments for AKI is still a relevant issue. In this context arises the question as to whether moderate, not extenuating, exercise could, on some level, prevent AKI. Several studies have shown that moderate exercise can help reduce tissue damage and increase the functional recovery of the kidneys after an acute injury. In particular, the immune system can be modulated by exercise, leading to a better recovery from different pathologies. In this review, we aimed to explore the role of exercise not as a trigger of AKI, but as a modulator of the inflammatory/immune system in the prevention or recovery from AKI in different scenarios. In AKI induced by ischemia and reperfusion, sepsis, diabetes, antibiotics, or chemotherapy, regular and/or moderate exercise could modulate the immune system toward a more regulatory immune response, presenting, in general, an anti-inflammatory profile. Exercise was shown to diminish oxidative stress, inflammatory markers (caspase-3, lactate dehydrogenase, and nitric oxide), inflammatory cytokines (interleukin (IL)-1b, IL-6, IL-8, and tumor necrosis factor-α (TNF-α)), modulate lymphocytes to an immune suppressive phenotype, and decrease tumor necrosis factor-β (TGF-β), a cytokine associated with fibrosis development. Thus, it creates an AKI recovery environment with less tissue damage, hypoxia, apoptosis, or fibrosis. In conclusion, the practice of regular moderate physical exercise has an impact on the immune system, favoring a regulatory and anti-inflammatory profile that prevents the occurrence of AKI and/or assists in the recovery from AKI. Moderate exercise should be considered for patients with AKI as a complementary therapy.
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spelling pubmed-106231522023-11-04 Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation Costanti-Nascimento, Ana Carolina Brelaz-Abreu, Leonilia Bragança-Jardim, Elayne Pereira, Welbert de Oliveira Camara, Niels Olsen Saraiva Amano, Mariane Tami Front Immunol Immunology Regular and moderate exercise is being used for therapeutic purposes in treating several diseases, including cancer, cardiovascular diseases, arthritis, and even chronic kidney diseases (CKDs). Conversely, extenuating physical exercise has long been pointed out as one of the sources of acute kidney injury (AKI) due to its severe impact on the body’s physiology. AKI development is associated with increased tubular necrosis, which initiates a cascade of inflammatory responses. The latter involves cytokine production, immune cell (macrophages, lymphocytes, and neutrophils, among others) activation, and increased oxidative stress. AKI can induce prolonged fibrosis stimulation, leading to CKD development. The need for therapeutic alternative treatments for AKI is still a relevant issue. In this context arises the question as to whether moderate, not extenuating, exercise could, on some level, prevent AKI. Several studies have shown that moderate exercise can help reduce tissue damage and increase the functional recovery of the kidneys after an acute injury. In particular, the immune system can be modulated by exercise, leading to a better recovery from different pathologies. In this review, we aimed to explore the role of exercise not as a trigger of AKI, but as a modulator of the inflammatory/immune system in the prevention or recovery from AKI in different scenarios. In AKI induced by ischemia and reperfusion, sepsis, diabetes, antibiotics, or chemotherapy, regular and/or moderate exercise could modulate the immune system toward a more regulatory immune response, presenting, in general, an anti-inflammatory profile. Exercise was shown to diminish oxidative stress, inflammatory markers (caspase-3, lactate dehydrogenase, and nitric oxide), inflammatory cytokines (interleukin (IL)-1b, IL-6, IL-8, and tumor necrosis factor-α (TNF-α)), modulate lymphocytes to an immune suppressive phenotype, and decrease tumor necrosis factor-β (TGF-β), a cytokine associated with fibrosis development. Thus, it creates an AKI recovery environment with less tissue damage, hypoxia, apoptosis, or fibrosis. In conclusion, the practice of regular moderate physical exercise has an impact on the immune system, favoring a regulatory and anti-inflammatory profile that prevents the occurrence of AKI and/or assists in the recovery from AKI. Moderate exercise should be considered for patients with AKI as a complementary therapy. Frontiers Media S.A. 2023-10-20 /pmc/articles/PMC10623152/ /pubmed/37928533 http://dx.doi.org/10.3389/fimmu.2023.1212163 Text en Copyright © 2023 Costanti-Nascimento, Brelaz-Abreu, Bragança-Jardim, Pereira, Camara and Amano https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Costanti-Nascimento, Ana Carolina
Brelaz-Abreu, Leonilia
Bragança-Jardim, Elayne
Pereira, Welbert de Oliveira
Camara, Niels Olsen Saraiva
Amano, Mariane Tami
Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
title Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
title_full Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
title_fullStr Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
title_full_unstemmed Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
title_short Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
title_sort physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623152/
https://www.ncbi.nlm.nih.gov/pubmed/37928533
http://dx.doi.org/10.3389/fimmu.2023.1212163
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