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Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer
Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B‐AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623535/ https://www.ncbi.nlm.nih.gov/pubmed/37724356 http://dx.doi.org/10.1111/jcmm.17966 |
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author | Yeh, Jung‐Chun Chen, Yi‐Tzu Chou, Ying‐Erh Su, Shih‐Chi Chang, Lun‐Ching Chen, Yen‐Lin Lin, Chiao‐Wen Yang, Shun‐Fa |
author_facet | Yeh, Jung‐Chun Chen, Yi‐Tzu Chou, Ying‐Erh Su, Shih‐Chi Chang, Lun‐Ching Chen, Yen‐Lin Lin, Chiao‐Wen Yang, Shun‐Fa |
author_sort | Yeh, Jung‐Chun |
collection | PubMed |
description | Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B‐AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B‐AS1 single‐nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B‐AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analysed in 1060 OSCC cases and 1183 cancer‐free controls. No significant association of these five SNPs with the risk of developing OSCC was detected between the case and control group. However, while examining the clinical characteristics, patients bearing at least one minor allele of rs1333048 (CA and CC) were more inclined to develop late‐stage (stage III/IV, adjusted OR, 1.480; 95% CI, 1.129–1.940; p = 0.005) and large‐size (greater than 2 cm in the greatest dimension, adjusted OR, 1.347; 95% CI, 1.028–1.765; p = 0.031) tumours, as compared with those homologous for the major allele (AA). Further stratification analyses demonstrated that this genetic correlation with the advanced stage of disease was observed only in habitual betel quid chewers (adjusted OR, 1.480; 95% CI, 1.076–2.035; p = 0.016) or cigarette smokers (adjusted OR, 1.531; 95% CI, 1.136–2.063; p = 0.005) but not in patients who were not exposed to these major habitual risks. These data reveal an interactive effect of CDKN2B‐AS1 rs1333048 with habitual exposure to behavioural risks on the progression of oral cancer. |
format | Online Article Text |
id | pubmed-10623535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106235352023-11-04 Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer Yeh, Jung‐Chun Chen, Yi‐Tzu Chou, Ying‐Erh Su, Shih‐Chi Chang, Lun‐Ching Chen, Yen‐Lin Lin, Chiao‐Wen Yang, Shun‐Fa J Cell Mol Med Original Articles Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B‐AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B‐AS1 single‐nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B‐AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analysed in 1060 OSCC cases and 1183 cancer‐free controls. No significant association of these five SNPs with the risk of developing OSCC was detected between the case and control group. However, while examining the clinical characteristics, patients bearing at least one minor allele of rs1333048 (CA and CC) were more inclined to develop late‐stage (stage III/IV, adjusted OR, 1.480; 95% CI, 1.129–1.940; p = 0.005) and large‐size (greater than 2 cm in the greatest dimension, adjusted OR, 1.347; 95% CI, 1.028–1.765; p = 0.031) tumours, as compared with those homologous for the major allele (AA). Further stratification analyses demonstrated that this genetic correlation with the advanced stage of disease was observed only in habitual betel quid chewers (adjusted OR, 1.480; 95% CI, 1.076–2.035; p = 0.016) or cigarette smokers (adjusted OR, 1.531; 95% CI, 1.136–2.063; p = 0.005) but not in patients who were not exposed to these major habitual risks. These data reveal an interactive effect of CDKN2B‐AS1 rs1333048 with habitual exposure to behavioural risks on the progression of oral cancer. John Wiley and Sons Inc. 2023-09-19 /pmc/articles/PMC10623535/ /pubmed/37724356 http://dx.doi.org/10.1111/jcmm.17966 Text en © 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Yeh, Jung‐Chun Chen, Yi‐Tzu Chou, Ying‐Erh Su, Shih‐Chi Chang, Lun‐Ching Chen, Yen‐Lin Lin, Chiao‐Wen Yang, Shun‐Fa Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer |
title | Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer |
title_full | Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer |
title_fullStr | Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer |
title_full_unstemmed | Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer |
title_short | Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer |
title_sort | interactive effects of cdkn2b‐as1 gene polymorphism and habitual risk factors on oral cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623535/ https://www.ncbi.nlm.nih.gov/pubmed/37724356 http://dx.doi.org/10.1111/jcmm.17966 |
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