XBP1 promotes NRAS(G12D) pre‐B acute lymphoblastic leukaemia through IL‐7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS

Activating point mutations of the RAS gene act as driver mutations for a subset of precursor‐B cell acute lymphoblastic leukaemias (pre‐B ALL) and represent an ambitious target for therapeutic approaches. The X box‐binding protein 1 (XBP1), a key regulator of the unfolded protein response (UPR), is...

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Detalles Bibliográficos
Autores principales: Salimi, Azam, Schemionek‐Reinders, Mirle, Huber, Michael, Vieri, Margherita, Patterson, John B., Alten, Julia, Brümmendorf, Tim H., Kharabi Masouleh, Behzad, Appelmann, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623536/
https://www.ncbi.nlm.nih.gov/pubmed/37753803
http://dx.doi.org/10.1111/jcmm.17904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623536/
https://www.ncbi.nlm.nih.gov/pubmed/37753803
http://dx.doi.org/10.1111/jcmm.17904

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