Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor

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[Image: see text] The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks, including fatalities. Many SCRAs exhibit much higher efficacy and potency compared with the phytocannabinoid Δ(9)-tetrahydrocannabinol (TH...

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Detalles Bibliográficos
Autores principales: Yano, Hideaki, Chitsazi, Rezvan, Lucaj, Christopher, Tran, Phuong, Hoffman, Alexander F., Baumann, Michael H., Lupica, Carl R., Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623572/
https://www.ncbi.nlm.nih.gov/pubmed/37847546
http://dx.doi.org/10.1021/acschemneuro.3c00530

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