Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1

Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-type calcium channel activity and recent studies suggest tha...

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Detalles Bibliográficos
Autores principales: Cain, Stuart M., Alles, Sascha R. A., Gopaul, Ray, Bernier, Louis-Philippe, Yung, Andrew C., Bauman, Andrew, Yang, Yi, Baker, Glen B., Kozlowski, Piotr, MacVicar, Brian A., Snutch, Terrance P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623724/
https://www.ncbi.nlm.nih.gov/pubmed/37924146
http://dx.doi.org/10.1186/s13041-023-01062-6

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