Cargando…

FTO facilitates cancer metastasis by modifying the m(6)A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer

BACKGROUND: Emerging evidence suggests the critical roles of N(6)-methyladenosine (m(6)A) RNA modification in tumorigenesis and tumor progression. However, the role of m(6)A in non-small cell lung cancer (NSCLC) is still unclear. This study aimed to explore the role of the m(6)A demethylase fat mass...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Lirong, Wang, Anqi, Chen, Yuling, Cai, Xin, Li, Yue, Zhao, Jian, Zhang, Yang, Zhang, Weijie, Zhu, Jianjie, Zeng, Yuanyuan, Liu, Zeyi, Huang, Jian-an
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623768/ https://www.ncbi.nlm.nih.gov/pubmed/37919739 http://dx.doi.org/10.1186/s12964-023-01343-6

Ejemplares similares

Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression
por: Zhou, Jieqi, et al.
Publicado: (2022)

Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer
por: Fu, Yulong, et al.
Publicado: (2020)

FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis
por: Ruan, Dan-Yun, et al.
Publicado: (2021)

NPTX1 promotes metastasis via integrin/FAK signaling in gastric cancer
por: Yan, Hongfei, et al.
Publicado: (2019)

The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer
por: Zhang, Ruochen, et al.
Publicado: (2021)

Long noncoding RNA LINC00518 contributes to proliferation and metastasis in lung adenocarcinoma via the miR-335-3p/CTHRC1 Axis
por: Shen, Ruoyi, et al.
Publicado: (2022)

BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK
por: Du, Cheng, et al.
Publicado: (2016)

CPNE1 promotes non-small cell lung cancer progression by interacting with RACK1 via the MET signaling pathway
por: Wang, Anqi, et al.
Publicado: (2022)

NPTX1 Promotes Metastasis via Integrin/FAK Signaling in Gastric Cancer [Retraction]
Publicado: (2023)

Circ_0039908/miR-let-7c/RRM2 axis was identified played an important role in lung adenocarcinoma by integrated analysis
por: Zhang, Weijie, et al.
Publicado: (2022)

Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis
por: Huang, Chi-Ruei, et al.
Publicado: (2015)

EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway
por: Xu, Jian, et al.
Publicado: (2021)

Construction of a Prognostic Immune-Related LncRNA Risk Model for Lung Adenocarcinoma
por: Li, Yue, et al.
Publicado: (2021)

ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L
por: Zhang, Weijie, et al.
Publicado: (2021)

CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer
por: Zhu, Jianjie, et al.
Publicado: (2021)

Downregulation of KIAA1199 by miR‐486‐5p suppresses tumorigenesis in lung cancer
por: Wang, Anqi, et al.
Publicado: (2020)

EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
por: Zhang, Lin, et al.
Publicado: (2022)

KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
por: Du, Wenwen, et al.
Publicado: (2020)

Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling
por: Wu, Jun-I, et al.
Publicado: (2019)

Forkhead box L2 is a target of miR‐133b and plays an important role in the pathogenesis of non‐small cell lung cancer
por: Li, Juan, et al.
Publicado: (2023)

FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway
por: Jia, Jun, et al.
Publicado: (2014)

Anlotinib can overcome acquired resistance to EGFR‐TKIs via FGFR1 signaling in non‐small cell lung cancer without harboring EGFR T790M mutation
por: Lian, Zengzhi, et al.
Publicado: (2020)

Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer
por: Guo, Biying, et al.
Publicado: (2017)

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis
por: Golubovskaya, Vita M, et al.
Publicado: (2009)

Integrin and FAK Regulation of Human Pluripotent Stem Cells
por: Vitillo, Loriana, et al.
Publicado: (2017)

Emerging Roles of FTO in Neuropsychiatric Disorders
por: Chang, Rui, et al.
Publicado: (2022)

The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer
por: Zhang, Yang, et al.
Publicado: (2019)

Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway
por: Xiang, Xiaoyu, et al.
Publicado: (2018)

AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma
por: Liu, Ting, et al.
Publicado: (2020)

N6‐methyladenosine modification of CENPF mRNA facilitates gastric cancer metastasis via regulating FAK nuclear export
por: Xu, Penghui, et al.
Publicado: (2023)

LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling
por: Zhang, Caixia, et al.
Publicado: (2021)

FAK and talin: Who is taking whom to the integrin engagement party?
por: Serrels, Bryan, et al.
Publicado: (2012)

Graphene-Induced Osteogenic Differentiation Is Mediated by the Integrin/FAK Axis
por: Xie, Han, et al.
Publicado: (2019)

MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo
por: Zeng, Yuanyuan, et al.
Publicado: (2016)

Dietary delphinidin inhibits human colorectal cancer metastasis associating with upregulation of miR-204-3p and suppression of the integrin/FAK axis
por: Huang, Chi-Chou, et al.
Publicado: (2019)

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer
por: Tai, Yu-Ling, et al.
Publicado: (2015)

Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy
por: Xu, B, et al.
Publicado: (2017)

Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models
por: Qi, Ming, et al.
Publicado: (2022)

Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models
por: Qi, Ming, et al.
Publicado: (2023)

High expression of Copine 1 promotes cell growth and metastasis in human lung adenocarcinoma
por: Liu, Shunlin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_05l1ohl9ah2uolbrtqqnovsqg5