The role of lactate in cardiovascular diseases

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and atherosclerosis. Glycolysis process often has changed during these cardiovascular diseases. Lactate, the end-product of glycoly...

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Autores principales: Ouyang, Jun, Wang, Hui, Huang, Jiangnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623854/
https://www.ncbi.nlm.nih.gov/pubmed/37924124
http://dx.doi.org/10.1186/s12964-023-01350-7
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author Ouyang, Jun
Wang, Hui
Huang, Jiangnan
author_facet Ouyang, Jun
Wang, Hui
Huang, Jiangnan
author_sort Ouyang, Jun
collection PubMed
description Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and atherosclerosis. Glycolysis process often has changed during these cardiovascular diseases. Lactate, the end-product of glycolysis, has been overlooked in the past but has gradually been identified to play major biological functions in recent years. Similarly, the role of lactate in cardiovascular disease is gradually being recognized. Targeting lactate production, regulating lactate transport, and modulating circulating lactate levels may serve as potential strategies for the treatment of cardiovascular diseases in the future. The purpose of this review is to integrate relevant clinical and basic research on the role of lactate in the pathophysiological process of cardiovascular disease in recent years to clarify the important role of lactate in cardiovascular disease and to guide further studies exploring the role of lactate in cardiovascular and other diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01350-7.
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spelling pubmed-106238542023-11-04 The role of lactate in cardiovascular diseases Ouyang, Jun Wang, Hui Huang, Jiangnan Cell Commun Signal Review Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and atherosclerosis. Glycolysis process often has changed during these cardiovascular diseases. Lactate, the end-product of glycolysis, has been overlooked in the past but has gradually been identified to play major biological functions in recent years. Similarly, the role of lactate in cardiovascular disease is gradually being recognized. Targeting lactate production, regulating lactate transport, and modulating circulating lactate levels may serve as potential strategies for the treatment of cardiovascular diseases in the future. The purpose of this review is to integrate relevant clinical and basic research on the role of lactate in the pathophysiological process of cardiovascular disease in recent years to clarify the important role of lactate in cardiovascular disease and to guide further studies exploring the role of lactate in cardiovascular and other diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01350-7. BioMed Central 2023-11-03 /pmc/articles/PMC10623854/ /pubmed/37924124 http://dx.doi.org/10.1186/s12964-023-01350-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ouyang, Jun
Wang, Hui
Huang, Jiangnan
The role of lactate in cardiovascular diseases
title The role of lactate in cardiovascular diseases
title_full The role of lactate in cardiovascular diseases
title_fullStr The role of lactate in cardiovascular diseases
title_full_unstemmed The role of lactate in cardiovascular diseases
title_short The role of lactate in cardiovascular diseases
title_sort role of lactate in cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623854/
https://www.ncbi.nlm.nih.gov/pubmed/37924124
http://dx.doi.org/10.1186/s12964-023-01350-7
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