Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination

Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and p...

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Autores principales: Kainulainen, Markus H., Harmon, Jessica R., Whitesell, Amy N., Bergeron, Éric, Karaaslan, Elif, Cossaboom, Caitlin M., Malenfant, Jason H., Kofman, Aaron, Montgomery, Joel M., Choi, Mary J., Albariño, César G., Spiropoulou, Christina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Ebola
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623891/
https://www.ncbi.nlm.nih.gov/pubmed/37787119
http://dx.doi.org/10.1080/22221751.2023.2265660
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author Kainulainen, Markus H.
Harmon, Jessica R.
Whitesell, Amy N.
Bergeron, Éric
Karaaslan, Elif
Cossaboom, Caitlin M.
Malenfant, Jason H.
Kofman, Aaron
Montgomery, Joel M.
Choi, Mary J.
Albariño, César G.
Spiropoulou, Christina F.
author_facet Kainulainen, Markus H.
Harmon, Jessica R.
Whitesell, Amy N.
Bergeron, Éric
Karaaslan, Elif
Cossaboom, Caitlin M.
Malenfant, Jason H.
Kofman, Aaron
Montgomery, Joel M.
Choi, Mary J.
Albariño, César G.
Spiropoulou, Christina F.
author_sort Kainulainen, Markus H.
collection PubMed
description Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and probable cases. This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine.
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spelling pubmed-106238912023-11-04 Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination Kainulainen, Markus H. Harmon, Jessica R. Whitesell, Amy N. Bergeron, Éric Karaaslan, Elif Cossaboom, Caitlin M. Malenfant, Jason H. Kofman, Aaron Montgomery, Joel M. Choi, Mary J. Albariño, César G. Spiropoulou, Christina F. Emerg Microbes Infect Ebola Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and probable cases. This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine. Taylor & Francis 2023-10-03 /pmc/articles/PMC10623891/ /pubmed/37787119 http://dx.doi.org/10.1080/22221751.2023.2265660 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Ebola
Kainulainen, Markus H.
Harmon, Jessica R.
Whitesell, Amy N.
Bergeron, Éric
Karaaslan, Elif
Cossaboom, Caitlin M.
Malenfant, Jason H.
Kofman, Aaron
Montgomery, Joel M.
Choi, Mary J.
Albariño, César G.
Spiropoulou, Christina F.
Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
title Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
title_full Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
title_fullStr Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
title_full_unstemmed Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
title_short Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
title_sort recombinant sudan virus and evaluation of humoral cross-reactivity between ebola and sudan virus glycoproteins after infection or rvsv-δg-zebov-gp vaccination
topic Ebola
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623891/
https://www.ncbi.nlm.nih.gov/pubmed/37787119
http://dx.doi.org/10.1080/22221751.2023.2265660
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