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Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats

PURPOSE: To analyze the effects of Anacardium occidentale Linn on the healing of skin wounds. METHODS: Twenty Wistar male rats were distributed into four groups (with five animals each one): negative control group (NCG), treated with saline solution; cashew tree group (CG), treated with hydroalcohol...

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Autores principales: da Silva, Dafni Cleia Gaia, da Silva, Hanna Machado, Franco, Pedro Pastorini, do Carmo, Tomaz José Aquino Vasconcelos, dos Santos, Deivid Ramos, Silveira, Edvaldo Lima, Pinto, Ana Carla Godinho, de Andrade, Marcieni Ataíde, Chaves, Rosa Helena de Figueiredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624227/
https://www.ncbi.nlm.nih.gov/pubmed/36629623
http://dx.doi.org/10.1590/acb371006
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author da Silva, Dafni Cleia Gaia
da Silva, Hanna Machado
Franco, Pedro Pastorini
do Carmo, Tomaz José Aquino Vasconcelos
dos Santos, Deivid Ramos
Silveira, Edvaldo Lima
Pinto, Ana Carla Godinho
de Andrade, Marcieni Ataíde
Chaves, Rosa Helena de Figueiredo
author_facet da Silva, Dafni Cleia Gaia
da Silva, Hanna Machado
Franco, Pedro Pastorini
do Carmo, Tomaz José Aquino Vasconcelos
dos Santos, Deivid Ramos
Silveira, Edvaldo Lima
Pinto, Ana Carla Godinho
de Andrade, Marcieni Ataíde
Chaves, Rosa Helena de Figueiredo
author_sort da Silva, Dafni Cleia Gaia
collection PubMed
description PURPOSE: To analyze the effects of Anacardium occidentale Linn on the healing of skin wounds. METHODS: Twenty Wistar male rats were distributed into four groups (with five animals each one): negative control group (NCG), treated with saline solution; cashew tree group (CG), treated with hydroalcoholic extract of the bark of A. occidentale Linn; manipulated cashew tree group (MCG), with the ointment of extract of the bark of A. occidentale Linn; positive control group (PCG), treated with sunflower oil. All animals were examined daily, observing the macroscopic aspects of the surgical wound. Hematoxylin-eosin staining was used for tissue morphology analysis and Masson’s trichrome for better collagen fiber characterization. RESULTS: On day 7, the MCG group had the expansion of the surgical wound covered by crust, exceeding the initial limits. On day 21, the wounds were observed to be completely closed and epithelialized in the NCG and CG groups. PCG and MCG still had remnants of crusts on the wound. The NCG was the only one not to present an abscess in histopathological analysis. CONCLUSIONS: There was a prolongation of the healing phase of the animals treated with the extract, and the animals in the NCG showed a better outcome by histological analysis.
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spelling pubmed-106242272023-11-04 Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats da Silva, Dafni Cleia Gaia da Silva, Hanna Machado Franco, Pedro Pastorini do Carmo, Tomaz José Aquino Vasconcelos dos Santos, Deivid Ramos Silveira, Edvaldo Lima Pinto, Ana Carla Godinho de Andrade, Marcieni Ataíde Chaves, Rosa Helena de Figueiredo Acta Cir Bras Original Article PURPOSE: To analyze the effects of Anacardium occidentale Linn on the healing of skin wounds. METHODS: Twenty Wistar male rats were distributed into four groups (with five animals each one): negative control group (NCG), treated with saline solution; cashew tree group (CG), treated with hydroalcoholic extract of the bark of A. occidentale Linn; manipulated cashew tree group (MCG), with the ointment of extract of the bark of A. occidentale Linn; positive control group (PCG), treated with sunflower oil. All animals were examined daily, observing the macroscopic aspects of the surgical wound. Hematoxylin-eosin staining was used for tissue morphology analysis and Masson’s trichrome for better collagen fiber characterization. RESULTS: On day 7, the MCG group had the expansion of the surgical wound covered by crust, exceeding the initial limits. On day 21, the wounds were observed to be completely closed and epithelialized in the NCG and CG groups. PCG and MCG still had remnants of crusts on the wound. The NCG was the only one not to present an abscess in histopathological analysis. CONCLUSIONS: There was a prolongation of the healing phase of the animals treated with the extract, and the animals in the NCG showed a better outcome by histological analysis. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2023-01-06 /pmc/articles/PMC10624227/ /pubmed/36629623 http://dx.doi.org/10.1590/acb371006 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
da Silva, Dafni Cleia Gaia
da Silva, Hanna Machado
Franco, Pedro Pastorini
do Carmo, Tomaz José Aquino Vasconcelos
dos Santos, Deivid Ramos
Silveira, Edvaldo Lima
Pinto, Ana Carla Godinho
de Andrade, Marcieni Ataíde
Chaves, Rosa Helena de Figueiredo
Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
title Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
title_full Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
title_fullStr Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
title_full_unstemmed Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
title_short Anacardium occidentale L. (cajueiro) in the healing of skin wounds: an experimental study in rats
title_sort anacardium occidentale l. (cajueiro) in the healing of skin wounds: an experimental study in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624227/
https://www.ncbi.nlm.nih.gov/pubmed/36629623
http://dx.doi.org/10.1590/acb371006
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