POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing

Unintegrated retroviral DNA is transcriptionally silenced by host chromatin silencing factors. Here, we used the proteomics of isolated chromatin segments method to reveal viral and host factors associated with unintegrated HIV-1DNA involved in its silencing. By gene silencing using siRNAs, 46 facto...

Descripción completa

Detalles Bibliográficos
Autores principales: Thenin-Houssier, Suzie, Machida, Shinichi, Jahan, Cyprien, Bonnet-Madin, Lucie, Abbou, Scarlette, Chen, Heng-Chang, Tesfaye, Robel, Cuvier, Olivier, Benkirane, Monsef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624344/
https://www.ncbi.nlm.nih.gov/pubmed/37922361
http://dx.doi.org/10.1126/sciadv.adh3642

Ejemplares similares

Ejemplares similares