Copper drives prion protein phase separation and modulates aggregation

Prion diseases are characterized by prion protein (PrP) transmissible aggregation and neurodegeneration, which has been linked to oxidative stress. The physiological function of PrP seems related to sequestering of redox-active Cu(2+), and Cu(2+) dyshomeostasis is observed in prion disease brain. It...

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Detalles Bibliográficos
Autores principales: do Amaral, Mariana Juliani, Mohapatra, Satabdee, Passos, Aline Ribeiro, Lopes da Silva, Taiana Sousa, Carvalho, Renato Sampaio, da Silva Almeida, Marcius, Pinheiro, Anderson Sá, Wegmann, Susanne, Cordeiro, Yraima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624353/
https://www.ncbi.nlm.nih.gov/pubmed/37922348
http://dx.doi.org/10.1126/sciadv.adi7347

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