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Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes

Mutational signatures represent a genomic footprint of endogenous and exogenous mutational processes through tumor evolution. However, their functional impact on the proteome remains incompletely understood. We analyzed the protein-coding impact of single-base substitution (SBS) signatures in 12,341...

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Detalles Bibliográficos
Autores principales:	Adler, Nina, Bahcheli, Alexander T., Cheng, Kevin C. L., Al-Zahrani, Khalid N., Slobodyanyuk, Mykhaylo, Pellegrina, Diogo, Schramek, Daniel, Reimand, Jüri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624356/ https://www.ncbi.nlm.nih.gov/pubmed/37922356 http://dx.doi.org/10.1126/sciadv.adh3083

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