Cargando…

Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes

Mutational signatures represent a genomic footprint of endogenous and exogenous mutational processes through tumor evolution. However, their functional impact on the proteome remains incompletely understood. We analyzed the protein-coding impact of single-base substitution (SBS) signatures in 12,341...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adler, Nina, Bahcheli, Alexander T., Cheng, Kevin C. L., Al-Zahrani, Khalid N., Slobodyanyuk, Mykhaylo, Pellegrina, Diogo, Schramek, Daniel, Reimand, Jüri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624356/ https://www.ncbi.nlm.nih.gov/pubmed/37922356 http://dx.doi.org/10.1126/sciadv.adh3083

Ejemplares similares

Human phospho‐signaling networks of SARS‐CoV‐2 infection are rewired by population genetic variants
por: Pellegrina, Diogo, et al.
Publicado: (2022)

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition
por: Shaban, Nadine M., et al.
Publicado: (2022)

Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase
por: Ito, Fumiaki, et al.
Publicado: (2023)

Untangling the roles of TOP2A and TOP2B in transcription and cancer
por: Uusküla-Reimand, Liis, et al.
Publicado: (2022)

Next-generation T cell–activating vaccination increases influenza virus mutation prevalence
por: Bull, Maireid B., et al.
Publicado: (2022)

Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization
por: Zhang, Kehan, et al.
Publicado: (2021)

The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation
por: Guo, Chenxu, et al.
Publicado: (2022)

Mutation-induced DNMT1 cleavage drives neurodegenerative disease
por: Wang, Wencai, et al.
Publicado: (2021)

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
por: Howes, Anna C., et al.
Publicado: (2023)

The causal mutation leading to sweetness in modern white lupin cultivars
por: Mancinotti, Davide, et al.
Publicado: (2023)

Truncated jarid2 and kdm6b transcripts are associated with temperature-induced sex reversal during development in a dragon lizard
por: Whiteley, Sarah L., et al.
Publicado: (2022)

A naturally arising broad and potent CD4-binding site antibody with low somatic mutation
por: Barnes, Christopher O., et al.
Publicado: (2022)

A somatic mutation in moesin drives progression into acute myeloid leukemia
por: Yuan, Ouyang, et al.
Publicado: (2022)

Cancer-driving mutations are enriched in genic regions intolerant to germline variation
por: Vitsios, Dimitrios, et al.
Publicado: (2022)

DNA replication initiation shapes the mutational landscape and expression of the human genome
por: Murat, Pierre, et al.
Publicado: (2022)

Parental mutations influence wild-type offspring via transcriptional adaptation
por: Jiang, Zhen, et al.
Publicado: (2022)

Epistasis between promoter activity and coding mutations shapes gene evolvability
por: Cisneros, Angel F., et al.
Publicado: (2023)

De novo human brain enhancers created by single-nucleotide mutations
por: Li, Shan, et al.
Publicado: (2023)

The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
por: Weinstock, Joshua S., et al.
Publicado: (2023)

How can same-gene mutations promote both cancer and developmental disorders?
por: Nussinov, Ruth, et al.
Publicado: (2022)

Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission
por: Zhang, Haixin, et al.
Publicado: (2021)

Loss-of-function mutations in CEP78 cause male infertility in humans and mice
por: Zhang, Xueguang, et al.
Publicado: (2022)

Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma
por: Rodriguez, Sara, et al.
Publicado: (2022)

A dominant tubulin mutation causes cerebellar neurodegeneration in a genetic model of tubulinopathy
por: Fertuzinhos, Sofia, et al.
Publicado: (2022)

CancerVar: An artificial intelligence–empowered platform for clinical interpretation of somatic mutations in cancer
por: Li, Quan, et al.
Publicado: (2022)

Single-molecule, quantitative detection of low-abundance somatic mutations by high-throughput sequencing
por: Maslov, Alexander Y., et al.
Publicado: (2022)

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency
por: Rota, Ioanna A., et al.
Publicado: (2021)

Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine
por: Yang, Nien-Du, et al.
Publicado: (2022)

H-ABC– and dystonia-causing TUBB4A mutations show distinct pathogenic effects
por: Krajka, Victor, et al.
Publicado: (2022)

Discovery of super–insecticide-resistant dengue mosquitoes in Asia: Threats of concomitant knockdown resistance mutations
por: Kasai, Shinji, et al.
Publicado: (2022)

Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise
por: Liu, Li-Man, et al.
Publicado: (2023)

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation
por: Carvalhal, Sara, et al.
Publicado: (2022)

Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer
por: Ferguson, Scott, et al.
Publicado: (2022)

Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration
por: Langouët, Maéva, et al.
Publicado: (2022)

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
por: Li, Peng, et al.
Publicado: (2023)

Genotype-specific precision tumor therapy using mitochondrial DNA mutation-induced drug release system
por: Li, Yanan, et al.
Publicado: (2023)

Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer
por: Fang, Hu, et al.
Publicado: (2021)

Biallelic germline mutations in MAD1L1 induce a syndrome of aneuploidy with high tumor susceptibility
por: Villarroya-Beltri, Carolina, et al.
Publicado: (2022)

Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy
por: Wong, Ho Yi, et al.
Publicado: (2023)

Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas
por: Tiek, Deanna M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bkf29ni98psiobe2b2bmm9nc8n