Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

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A long-standing goal of amyloid research has been to characterize the structural basis of the rate-determining nucleating event. However, the ephemeral nature of nucleation has made this goal unachievable with existing biochemistry, structural biology, and computational approaches. Here, we addresse...

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Detalles Bibliográficos
Autores principales: Kandola, Tej, Venkatesan, Shriram, Zhang, Jiahui, Lerbakken, Brooklyn T, Von Schulze, Alex, Blanck, Jillian F, Wu, Jianzheng, Unruh, Jay R, Berry, Paula, Lange, Jeffrey J, Box, Andrew C, Cook, Malcolm, Sagui, Celeste, Halfmann, Randal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624427/
https://www.ncbi.nlm.nih.gov/pubmed/37921648
http://dx.doi.org/10.7554/eLife.86939
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