A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease

Synapse loss strongly correlates with cognitive decline in Alzheimer’s disease (AD), but the underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to synapse dysfunction and loss in AD. Consistently, a variant of the LRP6 receptor, (LRP6-Val), with reduced Wnt signaling, i...

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Detalles Bibliográficos
Autores principales: Jones, Megan E., Büchler, Johanna, Dufor, Tom, Palomer, Ernest, Teo, Samuel, Martin-Flores, Nuria, Boroviak, Katharina, Metzakopian, Emmanouil, Gibb, Alasdair, Salinas, Patricia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624429/
https://www.ncbi.nlm.nih.gov/pubmed/36638182
http://dx.doi.org/10.1126/sciadv.abo7421

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