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Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood

BACKGROUND: Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity. METHODS: A total of 298 chil...

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Autores principales: Grandjean, Philippe, Shih, Yu-Hsuan, Jørgensen, Louise Helskov, Nielsen, Flemming, Weihe, Pál, Budtz-Jørgensen, Esben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624607/
https://www.ncbi.nlm.nih.gov/pubmed/37316707
http://dx.doi.org/10.1038/s41390-023-02665-4
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author Grandjean, Philippe
Shih, Yu-Hsuan
Jørgensen, Louise Helskov
Nielsen, Flemming
Weihe, Pál
Budtz-Jørgensen, Esben
author_facet Grandjean, Philippe
Shih, Yu-Hsuan
Jørgensen, Louise Helskov
Nielsen, Flemming
Weihe, Pál
Budtz-Jørgensen, Esben
author_sort Grandjean, Philippe
collection PubMed
description BACKGROUND: Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity. METHODS: A total of 298 children from a prospective birth cohort were followed up through to age 9 years. Serum-PFAS was measured at birth and 18 months of age, while exposures during infancy were estimated by structural equations. Adiponectin, resistin, leptin, and the leptin receptor were measured in serum at age 9. Adjusted regression coefficients for estimated serum-PFAS concentrations were calculated, with additional consideration of the duration of breastfeeding and potential effect modification by sex. RESULTS: A doubling in estimated serum-PFAS concentrations, particularly at ages 6 and 12 months, was associated with a loss of about 10–15% in age 9 resistin concentrations, while other associations were much weaker. Sex dependence of the associations was not observed, and neither did the duration of breastfeeding affect outcomes at age 9. CONCLUSION: Lowered serum-resistin concentrations at age 9 years were most strongly associated with early postnatal PFAS exposures. These findings suggest that infancy may represent a vulnerable time window for some aspects of metabolic programming that may be affected by PFAS exposure. IMPACT: Serum-PFAS concentrations during infancy can be estimated in the absence of blood samples. Adipokine concentrations were measured at age 9 years as metabolic biomarkers. Resistin was significantly lower in children with elevated PFAS exposures in infancy. The findings suggest that early postnatal PFAS exposures may affect subsequent metabolic health. Assessment of infancy vulnerability to PFAS can be explored using estimated serum-PFAS concentrations.
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spelling pubmed-106246072023-11-05 Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood Grandjean, Philippe Shih, Yu-Hsuan Jørgensen, Louise Helskov Nielsen, Flemming Weihe, Pál Budtz-Jørgensen, Esben Pediatr Res Population Study Article BACKGROUND: Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity. METHODS: A total of 298 children from a prospective birth cohort were followed up through to age 9 years. Serum-PFAS was measured at birth and 18 months of age, while exposures during infancy were estimated by structural equations. Adiponectin, resistin, leptin, and the leptin receptor were measured in serum at age 9. Adjusted regression coefficients for estimated serum-PFAS concentrations were calculated, with additional consideration of the duration of breastfeeding and potential effect modification by sex. RESULTS: A doubling in estimated serum-PFAS concentrations, particularly at ages 6 and 12 months, was associated with a loss of about 10–15% in age 9 resistin concentrations, while other associations were much weaker. Sex dependence of the associations was not observed, and neither did the duration of breastfeeding affect outcomes at age 9. CONCLUSION: Lowered serum-resistin concentrations at age 9 years were most strongly associated with early postnatal PFAS exposures. These findings suggest that infancy may represent a vulnerable time window for some aspects of metabolic programming that may be affected by PFAS exposure. IMPACT: Serum-PFAS concentrations during infancy can be estimated in the absence of blood samples. Adipokine concentrations were measured at age 9 years as metabolic biomarkers. Resistin was significantly lower in children with elevated PFAS exposures in infancy. The findings suggest that early postnatal PFAS exposures may affect subsequent metabolic health. Assessment of infancy vulnerability to PFAS can be explored using estimated serum-PFAS concentrations. Nature Publishing Group US 2023-06-14 2023 /pmc/articles/PMC10624607/ /pubmed/37316707 http://dx.doi.org/10.1038/s41390-023-02665-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Population Study Article
Grandjean, Philippe
Shih, Yu-Hsuan
Jørgensen, Louise Helskov
Nielsen, Flemming
Weihe, Pál
Budtz-Jørgensen, Esben
Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
title Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
title_full Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
title_fullStr Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
title_full_unstemmed Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
title_short Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
title_sort estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
topic Population Study Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624607/
https://www.ncbi.nlm.nih.gov/pubmed/37316707
http://dx.doi.org/10.1038/s41390-023-02665-4
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