Design of allosteric sites into rotary motor V(1)-ATPase by restoring lost function of pseudo-active sites

Allostery produces concerted functions of protein complexes by orchestrating the cooperative work between the constituent subunits. Here we describe an approach to create artificial allosteric sites in protein complexes. Certain protein complexes contain subunits with pseudo-active sites, which are...

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Detalles Bibliográficos
Autores principales: Kosugi, Takahiro, Iida, Tatsuya, Tanabe, Mikio, Iino, Ryota, Koga, Nobuyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624635/
https://www.ncbi.nlm.nih.gov/pubmed/37414880
http://dx.doi.org/10.1038/s41557-023-01256-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624635/
https://www.ncbi.nlm.nih.gov/pubmed/37414880
http://dx.doi.org/10.1038/s41557-023-01256-4

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