Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease in rhesus macaques inoculated with the severe acute respiratory syndrome coronavirus 2 (SARS-...

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Detalles Bibliográficos
Autores principales: Streblow, Daniel N., Hirsch, Alec J., Stanton, Jeffrey J., Lewis, Anne D., Colgin, Lois, Hessell, Ann J., Kreklywich, Craig N., Smith, Jessica L., Sutton, William F., Chauvin, David, Woo, Jennifer, Bimber, Benjamin N., LeBlanc, Cierra N., Acharya, Sonia N., O’Roak, Brian J., Sardar, Harjinder, Sajadi, Mohammad M., Tehrani, Zahra R., Walter, Mark R., Martinez-Sobrido, Luis, Kobie, James J., Reader, Rachel J., Olstad, Katherine J., Hobbs, Theodore R., Saphire, Erica Ollmann, Schendel, Sharon L., Carnahan, Robert H., Knoch, Jonas, Branco, Luis M., Crowe, James E., Van Rompay, Koen K. A., Lovalenti, Phillip, Vu Truong, Forthal, Donald N., Haigwood, Nancy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624670/
https://www.ncbi.nlm.nih.gov/pubmed/37923717
http://dx.doi.org/10.1038/s41467-023-42440-x

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