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Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism

BACKGROUND AND OBJECTIVES: Acute inflammation caused by infections or sepsis can impact pharmacokinetics. We used a model-based analysis to evaluate the effect of acute inflammation as represented by interleukin-6 (IL-6) levels on drug clearance, focusing on renal glomerular filtration rate (GFR) an...

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Detalles Bibliográficos
Autores principales:	Liu, Feiyan, Aulin, Linda B. S., Manson, Martijn L., Krekels, Elke H. J., van Hasselt, J. G. Coen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624742/ https://www.ncbi.nlm.nih.gov/pubmed/37715056 http://dx.doi.org/10.1007/s13318-023-00852-6

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