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Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan as...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624811/ https://www.ncbi.nlm.nih.gov/pubmed/37923804 http://dx.doi.org/10.1038/s42003-023-05454-1 |
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| author | Tin, Adrienne Fohner, Alison E. Yang, Qiong Brody, Jennifer A. Davies, Gail Yao, Jie Liu, Dan Caro, Ilana Lindbohm, Joni V. Duggan, Michael R. Meirelles, Osorio Harris, Sarah E. Gudmundsdottir, Valborg Taylor, Adele M. Henry, Albert Beiser, Alexa S. Shojaie, Ali Coors, Annabell Fitzpatrick, Annette L. Langenberg, Claudia Satizabal, Claudia L. Sitlani, Colleen M. Wheeler, Eleanor Tucker-Drob, Elliot M. Bressler, Jan Coresh, Josef Bis, Joshua C. Candia, Julián Jennings, Lori L. Pietzner, Maik Lathrop, Mark Lopez, Oscar L. Redmond, Paul Gerszten, Robert E. Rich, Stephen S. Heckbert, Susan R. Austin, Thomas R. Hughes, Timothy M. Tanaka, Toshiko Emilsson, Valur Vasan, Ramachandran S. Guo, Xiuqing Zhu, Yineng Tzourio, Christophe Rotter, Jerome I. Walker, Keenan A. Ferrucci, Luigi Kivimäki, Mika Breteler, Monique M. B. Cox, Simon R. Debette, Stephanie Mosley, Thomas H. Gudnason, Vilmundur G. Launer, Lenore J. Psaty, Bruce M. Seshadri, Sudha Fornage, Myriam |
| author_facet | Tin, Adrienne Fohner, Alison E. Yang, Qiong Brody, Jennifer A. Davies, Gail Yao, Jie Liu, Dan Caro, Ilana Lindbohm, Joni V. Duggan, Michael R. Meirelles, Osorio Harris, Sarah E. Gudmundsdottir, Valborg Taylor, Adele M. Henry, Albert Beiser, Alexa S. Shojaie, Ali Coors, Annabell Fitzpatrick, Annette L. Langenberg, Claudia Satizabal, Claudia L. Sitlani, Colleen M. Wheeler, Eleanor Tucker-Drob, Elliot M. Bressler, Jan Coresh, Josef Bis, Joshua C. Candia, Julián Jennings, Lori L. Pietzner, Maik Lathrop, Mark Lopez, Oscar L. Redmond, Paul Gerszten, Robert E. Rich, Stephen S. Heckbert, Susan R. Austin, Thomas R. Hughes, Timothy M. Tanaka, Toshiko Emilsson, Valur Vasan, Ramachandran S. Guo, Xiuqing Zhu, Yineng Tzourio, Christophe Rotter, Jerome I. Walker, Keenan A. Ferrucci, Luigi Kivimäki, Mika Breteler, Monique M. B. Cox, Simon R. Debette, Stephanie Mosley, Thomas H. Gudnason, Vilmundur G. Launer, Lenore J. Psaty, Bruce M. Seshadri, Sudha Fornage, Myriam |
| author_sort | Tin, Adrienne |
| collection | PubMed |
| description | Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer’s disease (AD) risk (p = 2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p < 2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets. |
| format | Online Article Text |
| id | pubmed-10624811 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106248112023-11-05 Identification of circulating proteins associated with general cognitive function among middle-aged and older adults Tin, Adrienne Fohner, Alison E. Yang, Qiong Brody, Jennifer A. Davies, Gail Yao, Jie Liu, Dan Caro, Ilana Lindbohm, Joni V. Duggan, Michael R. Meirelles, Osorio Harris, Sarah E. Gudmundsdottir, Valborg Taylor, Adele M. Henry, Albert Beiser, Alexa S. Shojaie, Ali Coors, Annabell Fitzpatrick, Annette L. Langenberg, Claudia Satizabal, Claudia L. Sitlani, Colleen M. Wheeler, Eleanor Tucker-Drob, Elliot M. Bressler, Jan Coresh, Josef Bis, Joshua C. Candia, Julián Jennings, Lori L. Pietzner, Maik Lathrop, Mark Lopez, Oscar L. Redmond, Paul Gerszten, Robert E. Rich, Stephen S. Heckbert, Susan R. Austin, Thomas R. Hughes, Timothy M. Tanaka, Toshiko Emilsson, Valur Vasan, Ramachandran S. Guo, Xiuqing Zhu, Yineng Tzourio, Christophe Rotter, Jerome I. Walker, Keenan A. Ferrucci, Luigi Kivimäki, Mika Breteler, Monique M. B. Cox, Simon R. Debette, Stephanie Mosley, Thomas H. Gudnason, Vilmundur G. Launer, Lenore J. Psaty, Bruce M. Seshadri, Sudha Fornage, Myriam Commun Biol Article Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer’s disease (AD) risk (p = 2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p < 2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets. Nature Publishing Group UK 2023-11-03 /pmc/articles/PMC10624811/ /pubmed/37923804 http://dx.doi.org/10.1038/s42003-023-05454-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Tin, Adrienne Fohner, Alison E. Yang, Qiong Brody, Jennifer A. Davies, Gail Yao, Jie Liu, Dan Caro, Ilana Lindbohm, Joni V. Duggan, Michael R. Meirelles, Osorio Harris, Sarah E. Gudmundsdottir, Valborg Taylor, Adele M. Henry, Albert Beiser, Alexa S. Shojaie, Ali Coors, Annabell Fitzpatrick, Annette L. Langenberg, Claudia Satizabal, Claudia L. Sitlani, Colleen M. Wheeler, Eleanor Tucker-Drob, Elliot M. Bressler, Jan Coresh, Josef Bis, Joshua C. Candia, Julián Jennings, Lori L. Pietzner, Maik Lathrop, Mark Lopez, Oscar L. Redmond, Paul Gerszten, Robert E. Rich, Stephen S. Heckbert, Susan R. Austin, Thomas R. Hughes, Timothy M. Tanaka, Toshiko Emilsson, Valur Vasan, Ramachandran S. Guo, Xiuqing Zhu, Yineng Tzourio, Christophe Rotter, Jerome I. Walker, Keenan A. Ferrucci, Luigi Kivimäki, Mika Breteler, Monique M. B. Cox, Simon R. Debette, Stephanie Mosley, Thomas H. Gudnason, Vilmundur G. Launer, Lenore J. Psaty, Bruce M. Seshadri, Sudha Fornage, Myriam Identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| title | Identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| title_full | Identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| title_fullStr | Identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| title_full_unstemmed | Identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| title_short | Identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| title_sort | identification of circulating proteins associated with general cognitive function among middle-aged and older adults |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624811/ https://www.ncbi.nlm.nih.gov/pubmed/37923804 http://dx.doi.org/10.1038/s42003-023-05454-1 |
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