Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains unexplored. Here, we find that low levels of glycolytic metabol...

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Detalles Bibliográficos
Autores principales: Wu, Yu-Qing, Zhang, Chen-Song, Xiong, Jinye, Cai, Dong-Qi, Wang, Chen-Zhe, Wang, Yu, Liu, Yan-Hui, Li, Yiming, Wu, Jian, Wu, Jianfeng, Lan, Bin, Wang, Xuefeng, Chen, Siwei, Cao, Xianglei, Wei, Xiaoyan, Hu, Hui-Hui, Guo, Huiling, Yu, Yaxin, Ghafoor, Abdul, Xie, Changchuan, Wu, Yaying, Xu, Zheni, Zhang, Cixiong, Zhu, Mingxia, Huang, Xi, Sun, Xiufeng, Lin, Shu-Yong, Piao, Hai-Long, Zhou, Jianyin, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624847/
https://www.ncbi.nlm.nih.gov/pubmed/37726403
http://dx.doi.org/10.1038/s41422-023-00874-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624847/
https://www.ncbi.nlm.nih.gov/pubmed/37726403
http://dx.doi.org/10.1038/s41422-023-00874-4

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