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Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1

Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infection is known to affect the NK cell pool, the additional imp...

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Autores principales: Alrubayyi, Aljawharah, Touizer, Emma, Hameiri-Bowen, Dan, Charlton, Bethany, Gea-Mallorquí, Ester, Hussain, Noshin, da Costa, Kelly A. S., Ford, Rosemarie, Rees-Spear, Chloe, Fox, Thomas A., Williams, Ian, Waters, Laura, Barber, Tristan J., Burns, Fiona, Kinloch, Sabine, Morris, Emma, Rowland-Jones, Sarah, McCoy, Laura E., Peppa, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624865/
https://www.ncbi.nlm.nih.gov/pubmed/37923825
http://dx.doi.org/10.1038/s41598-023-45412-9
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author Alrubayyi, Aljawharah
Touizer, Emma
Hameiri-Bowen, Dan
Charlton, Bethany
Gea-Mallorquí, Ester
Hussain, Noshin
da Costa, Kelly A. S.
Ford, Rosemarie
Rees-Spear, Chloe
Fox, Thomas A.
Williams, Ian
Waters, Laura
Barber, Tristan J.
Burns, Fiona
Kinloch, Sabine
Morris, Emma
Rowland-Jones, Sarah
McCoy, Laura E.
Peppa, Dimitra
author_facet Alrubayyi, Aljawharah
Touizer, Emma
Hameiri-Bowen, Dan
Charlton, Bethany
Gea-Mallorquí, Ester
Hussain, Noshin
da Costa, Kelly A. S.
Ford, Rosemarie
Rees-Spear, Chloe
Fox, Thomas A.
Williams, Ian
Waters, Laura
Barber, Tristan J.
Burns, Fiona
Kinloch, Sabine
Morris, Emma
Rowland-Jones, Sarah
McCoy, Laura E.
Peppa, Dimitra
author_sort Alrubayyi, Aljawharah
collection PubMed
description Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infection is known to affect the NK cell pool, the additional impact of SARS-CoV-2 infection and/or vaccination on NK cell responses in people living with HIV (PLWH) has remained unexplored. Our data show that SARS-CoV-2 infection skews NK cells towards a more differentiated/adaptive CD57(+)FcεRIγ(−) phenotype in PLWH. A similar subset was induced following vaccination in SARS-CoV-2 naïve PLWH in addition to a CD56(bright) population with cytotoxic potential. Antibody-dependent NK cell function showed robust and durable responses to Spike up to 148 days post-infection, with responses enriched in adaptive NK cells. NK cell responses were further boosted by the first vaccine dose in SARS-CoV-2 exposed individuals and peaked after the second dose in SARS-CoV-2 naïve PLWH. The presence of adaptive NK cells associated with the magnitude of cellular and humoral responses. These data suggest that features of adaptive NK cells can be effectively engaged to complement and boost vaccine-induced adaptive immunity in potentially more vulnerable groups such as PLWH.
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spelling pubmed-106248652023-11-05 Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1 Alrubayyi, Aljawharah Touizer, Emma Hameiri-Bowen, Dan Charlton, Bethany Gea-Mallorquí, Ester Hussain, Noshin da Costa, Kelly A. S. Ford, Rosemarie Rees-Spear, Chloe Fox, Thomas A. Williams, Ian Waters, Laura Barber, Tristan J. Burns, Fiona Kinloch, Sabine Morris, Emma Rowland-Jones, Sarah McCoy, Laura E. Peppa, Dimitra Sci Rep Article Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infection is known to affect the NK cell pool, the additional impact of SARS-CoV-2 infection and/or vaccination on NK cell responses in people living with HIV (PLWH) has remained unexplored. Our data show that SARS-CoV-2 infection skews NK cells towards a more differentiated/adaptive CD57(+)FcεRIγ(−) phenotype in PLWH. A similar subset was induced following vaccination in SARS-CoV-2 naïve PLWH in addition to a CD56(bright) population with cytotoxic potential. Antibody-dependent NK cell function showed robust and durable responses to Spike up to 148 days post-infection, with responses enriched in adaptive NK cells. NK cell responses were further boosted by the first vaccine dose in SARS-CoV-2 exposed individuals and peaked after the second dose in SARS-CoV-2 naïve PLWH. The presence of adaptive NK cells associated with the magnitude of cellular and humoral responses. These data suggest that features of adaptive NK cells can be effectively engaged to complement and boost vaccine-induced adaptive immunity in potentially more vulnerable groups such as PLWH. Nature Publishing Group UK 2023-11-03 /pmc/articles/PMC10624865/ /pubmed/37923825 http://dx.doi.org/10.1038/s41598-023-45412-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Alrubayyi, Aljawharah
Touizer, Emma
Hameiri-Bowen, Dan
Charlton, Bethany
Gea-Mallorquí, Ester
Hussain, Noshin
da Costa, Kelly A. S.
Ford, Rosemarie
Rees-Spear, Chloe
Fox, Thomas A.
Williams, Ian
Waters, Laura
Barber, Tristan J.
Burns, Fiona
Kinloch, Sabine
Morris, Emma
Rowland-Jones, Sarah
McCoy, Laura E.
Peppa, Dimitra
Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1
title Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1
title_full Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1
title_fullStr Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1
title_full_unstemmed Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1
title_short Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1
title_sort natural killer cell responses during sars-cov-2 infection and vaccination in people living with hiv-1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624865/
https://www.ncbi.nlm.nih.gov/pubmed/37923825
http://dx.doi.org/10.1038/s41598-023-45412-9
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