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Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recover the Drosophila ortholog of APP, Appl, in a...

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Detalles Bibliográficos
Autores principales:	Nithianandam, Vanitha, Bukhari, Hassan, Leventhal, Matthew J., Battaglia, Rachel A., Dong, Xianjun, Fraenkel, Ernest, Feany, Mel B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624868/ https://www.ncbi.nlm.nih.gov/pubmed/37923712 http://dx.doi.org/10.1038/s41467-023-42822-1

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