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Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings
Obsessive–compulsive disorder (OCD) is a mental condition that affects many people and is characterized by recurring obsessions and compulsions. It significantly impacts individuals’ ability to function ordinarily daily, affecting people of all ages. This study aimed to investigate whether or not th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624891/ https://www.ncbi.nlm.nih.gov/pubmed/37923827 http://dx.doi.org/10.1038/s41598-023-46401-8 |
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author | Sarker, Rapty Qusar, M. M. A. Shalahuddin Islam, Sardar Mohammad Ashraful Bhuiyan, Mohiuddin Ahmed Islam, Md. Rabiul |
author_facet | Sarker, Rapty Qusar, M. M. A. Shalahuddin Islam, Sardar Mohammad Ashraful Bhuiyan, Mohiuddin Ahmed Islam, Md. Rabiul |
author_sort | Sarker, Rapty |
collection | PubMed |
description | Obsessive–compulsive disorder (OCD) is a mental condition that affects many people and is characterized by recurring obsessions and compulsions. It significantly impacts individuals’ ability to function ordinarily daily, affecting people of all ages. This study aimed to investigate whether or not the cytokines granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17) are involved in the pathophysiology of OCD. A case–control study with 50 OCD patients and 38 healthy volunteers served as the controls for this investigation. The levels of GM-CSF and IL-17 in the serum of both groups were measured with enzyme-linked immunosorbent assay (ELISA) kits. In addition, the sociodemographic characteristics of the population under study were studied. Based on the findings of this study, OCD patients had significantly elevated levels of IL-17 than the controls, it appears that there may be a function for IL-17 in the pathophysiology of OCD. It was also discovered that the severity of OCD and IL-17 levels had a significant positive correlation. On the other hand, when comparing the levels of GM-CSF, there was no significant difference between the patients and the controls. This study provides evidence supporting the involvement of cytokine IL-17 in the pathophysiology of OCD. This study suggests IL-17 as a diagnostic biomarker for OCD and adds to our knowledge of the function that the immune system plays in this condition. |
format | Online Article Text |
id | pubmed-10624891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106248912023-11-05 Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings Sarker, Rapty Qusar, M. M. A. Shalahuddin Islam, Sardar Mohammad Ashraful Bhuiyan, Mohiuddin Ahmed Islam, Md. Rabiul Sci Rep Article Obsessive–compulsive disorder (OCD) is a mental condition that affects many people and is characterized by recurring obsessions and compulsions. It significantly impacts individuals’ ability to function ordinarily daily, affecting people of all ages. This study aimed to investigate whether or not the cytokines granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17) are involved in the pathophysiology of OCD. A case–control study with 50 OCD patients and 38 healthy volunteers served as the controls for this investigation. The levels of GM-CSF and IL-17 in the serum of both groups were measured with enzyme-linked immunosorbent assay (ELISA) kits. In addition, the sociodemographic characteristics of the population under study were studied. Based on the findings of this study, OCD patients had significantly elevated levels of IL-17 than the controls, it appears that there may be a function for IL-17 in the pathophysiology of OCD. It was also discovered that the severity of OCD and IL-17 levels had a significant positive correlation. On the other hand, when comparing the levels of GM-CSF, there was no significant difference between the patients and the controls. This study provides evidence supporting the involvement of cytokine IL-17 in the pathophysiology of OCD. This study suggests IL-17 as a diagnostic biomarker for OCD and adds to our knowledge of the function that the immune system plays in this condition. Nature Publishing Group UK 2023-11-03 /pmc/articles/PMC10624891/ /pubmed/37923827 http://dx.doi.org/10.1038/s41598-023-46401-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sarker, Rapty Qusar, M. M. A. Shalahuddin Islam, Sardar Mohammad Ashraful Bhuiyan, Mohiuddin Ahmed Islam, Md. Rabiul Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
title | Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
title_full | Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
title_fullStr | Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
title_full_unstemmed | Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
title_short | Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
title_sort | association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive–compulsive disorder: a case–control study findings |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624891/ https://www.ncbi.nlm.nih.gov/pubmed/37923827 http://dx.doi.org/10.1038/s41598-023-46401-8 |
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