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Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity
It is important for allocation of resources to predict those COVID patients at high risk of dying or organ failure. Early signals to initiate cellular events of host immunity can be derived from essential fatty acid metabolites preceding the cascade of proinflammatory signals. Much research has focu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624896/ https://www.ncbi.nlm.nih.gov/pubmed/37923927 http://dx.doi.org/10.1038/s41598-023-46247-0 |
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author | Mazurak, Vera C. Rivas-Serna, Irma Magaly Parsons, Sarah R. Monirujjaman, Md Maybank, Krista E. Woo, Stanley K. Rewa, Oleksa G. Cave, Andrew J. Richard, Caroline Clandinin, M. Thomas |
author_facet | Mazurak, Vera C. Rivas-Serna, Irma Magaly Parsons, Sarah R. Monirujjaman, Md Maybank, Krista E. Woo, Stanley K. Rewa, Oleksa G. Cave, Andrew J. Richard, Caroline Clandinin, M. Thomas |
author_sort | Mazurak, Vera C. |
collection | PubMed |
description | It is important for allocation of resources to predict those COVID patients at high risk of dying or organ failure. Early signals to initiate cellular events of host immunity can be derived from essential fatty acid metabolites preceding the cascade of proinflammatory signals. Much research has focused on understanding later proinflammatory responses. We assessed if remodelling of plasma phospholipid content of essential fatty acids by the COVID-19 virus provides early markers for potential death and disease severity. Here we show that, at hospital admission, COVID-19 infected subjects who survive exhibit higher proportions of C20:4n-6 in plasma phospholipids concurrent with marked proinflammatory cytokine elevation in plasma compared to healthy subjects. In contrast, more than half of subjects who die of this virus exhibit very low C18:2n-6 and C20:4n-6 content in plasma phospholipids on hospital admission compared with healthy control subjects. Moreover, in these subjects who die, the low level of primary inflammatory signals indicates limited or aberrant stimulation of host immunity. We conclude that COVID-19 infection results in early fundamental remodelling of essential fatty acid metabolism. In subjects with high mortality, it appears that plasma n-6 fatty acid content is too low to stimulate cellular events of host immunity. |
format | Online Article Text |
id | pubmed-10624896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106248962023-11-05 Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity Mazurak, Vera C. Rivas-Serna, Irma Magaly Parsons, Sarah R. Monirujjaman, Md Maybank, Krista E. Woo, Stanley K. Rewa, Oleksa G. Cave, Andrew J. Richard, Caroline Clandinin, M. Thomas Sci Rep Article It is important for allocation of resources to predict those COVID patients at high risk of dying or organ failure. Early signals to initiate cellular events of host immunity can be derived from essential fatty acid metabolites preceding the cascade of proinflammatory signals. Much research has focused on understanding later proinflammatory responses. We assessed if remodelling of plasma phospholipid content of essential fatty acids by the COVID-19 virus provides early markers for potential death and disease severity. Here we show that, at hospital admission, COVID-19 infected subjects who survive exhibit higher proportions of C20:4n-6 in plasma phospholipids concurrent with marked proinflammatory cytokine elevation in plasma compared to healthy subjects. In contrast, more than half of subjects who die of this virus exhibit very low C18:2n-6 and C20:4n-6 content in plasma phospholipids on hospital admission compared with healthy control subjects. Moreover, in these subjects who die, the low level of primary inflammatory signals indicates limited or aberrant stimulation of host immunity. We conclude that COVID-19 infection results in early fundamental remodelling of essential fatty acid metabolism. In subjects with high mortality, it appears that plasma n-6 fatty acid content is too low to stimulate cellular events of host immunity. Nature Publishing Group UK 2023-11-03 /pmc/articles/PMC10624896/ /pubmed/37923927 http://dx.doi.org/10.1038/s41598-023-46247-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mazurak, Vera C. Rivas-Serna, Irma Magaly Parsons, Sarah R. Monirujjaman, Md Maybank, Krista E. Woo, Stanley K. Rewa, Oleksa G. Cave, Andrew J. Richard, Caroline Clandinin, M. Thomas Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity |
title | Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity |
title_full | Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity |
title_fullStr | Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity |
title_full_unstemmed | Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity |
title_short | Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity |
title_sort | plasma essential fatty acid on hospital admission is a marker of covid-19 disease severity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624896/ https://www.ncbi.nlm.nih.gov/pubmed/37923927 http://dx.doi.org/10.1038/s41598-023-46247-0 |
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