Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC

Lysine-specific demethylase 1 (LSD1) has been identified as an important epigenetic target, and recent advances in lung cancer therapy have highlighted the importance of targeting ferroptosis. However, the precise mechanisms by which LSD1 regulates ferroptosis remain elusive. In this study, we repor...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Linna, Yang, Han, Ren, Yufei, Ding, Yanli, Xu, Yichao, Zi, Xiaolin, Liu, Hongmin, He, Pengxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624898/
https://www.ncbi.nlm.nih.gov/pubmed/37923740
http://dx.doi.org/10.1038/s41419-023-06238-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624898/
https://www.ncbi.nlm.nih.gov/pubmed/37923740
http://dx.doi.org/10.1038/s41419-023-06238-5

Ejemplares similares