Cathepsin-facilitated invasion of BMI1-high hepatocellular carcinoma cells drives bile duct tumor thrombi formation

Bile duct tumor thrombosis (BDTT) is a complication mostly observed in patients with advanced hepatocellular carcinoma (HCC), causing jaundice and associated with poor clinical outcome. However, its underlying molecular mechanism is unclear. Here, we develop spontaneous preclinical HCC animal models...

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Detalles Bibliográficos
Autores principales: Xu, Lei-Bo, Qin, Yu-Fei, Su, Liangping, Huang, Cheng, Xu, Qiuping, Zhang, Rui, Shi, Xiang-De, Sun, Ruipu, Chen, Jiali, Song, Zhixiao, Jiang, Xue, Shang, Lihuan, Xiao, Gang, Kong, Xiangzhan, Liu, Chao, Wong, Ping-Pui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624910/
https://www.ncbi.nlm.nih.gov/pubmed/37923799
http://dx.doi.org/10.1038/s41467-023-42930-y

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