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A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals
In this comprehensive meta-regression analysis encompassing 79 randomized controlled trials, we observed that in populations assigned to a high sodium intake level exceeding 94 mmol, there was no discernible link between plasma aldosterone levels and sodium intake. However, among populations with no...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624927/ https://www.ncbi.nlm.nih.gov/pubmed/37923769 http://dx.doi.org/10.1038/s41598-023-46285-8 |
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author | Graudal, Niels Hubeck-Graudal, Thorbjørn Jurgens, Gesche |
author_facet | Graudal, Niels Hubeck-Graudal, Thorbjørn Jurgens, Gesche |
author_sort | Graudal, Niels |
collection | PubMed |
description | In this comprehensive meta-regression analysis encompassing 79 randomized controlled trials, we observed that in populations assigned to a high sodium intake level exceeding 94 mmol, there was no discernible link between plasma aldosterone levels and sodium intake. However, among populations with normal blood pressure subjected to a lower sodium intake, falling below 111 mmol (N = 1544), the association between sodium intake and plasma aldosterone levels manifested as a decrease of 192 pg/ml per 100 mmol of sodium (95% CI − 303 to − 81). In hypertensive populations (N = 1145), this association was less pronounced, with a reduction of 46 pg/ml per 100 mmol sodium, (95% CI − 112 to 20). Furthermore, in normotensive populations the plasma aldosterone increase associated with a decrease in sodium intake was 70 pg/ml per 100 mmol sodium (95% CI 27 to 113). In hypertensive populations, the observed increase was more modest, at 30 pg/ml per 100 mmol sodium, (95% CI 6.8 to 54). A limitation of this study lies in the absence of individual participant data. Our analysis included adjustments for potential effect-modifiers, encompassing bias estimation, which did not substantially alter these associations. One perspective of the present results may be to prompt a reconsideration of current sodium reduction recommendations. |
format | Online Article Text |
id | pubmed-10624927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106249272023-11-05 A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals Graudal, Niels Hubeck-Graudal, Thorbjørn Jurgens, Gesche Sci Rep Article In this comprehensive meta-regression analysis encompassing 79 randomized controlled trials, we observed that in populations assigned to a high sodium intake level exceeding 94 mmol, there was no discernible link between plasma aldosterone levels and sodium intake. However, among populations with normal blood pressure subjected to a lower sodium intake, falling below 111 mmol (N = 1544), the association between sodium intake and plasma aldosterone levels manifested as a decrease of 192 pg/ml per 100 mmol of sodium (95% CI − 303 to − 81). In hypertensive populations (N = 1145), this association was less pronounced, with a reduction of 46 pg/ml per 100 mmol sodium, (95% CI − 112 to 20). Furthermore, in normotensive populations the plasma aldosterone increase associated with a decrease in sodium intake was 70 pg/ml per 100 mmol sodium (95% CI 27 to 113). In hypertensive populations, the observed increase was more modest, at 30 pg/ml per 100 mmol sodium, (95% CI 6.8 to 54). A limitation of this study lies in the absence of individual participant data. Our analysis included adjustments for potential effect-modifiers, encompassing bias estimation, which did not substantially alter these associations. One perspective of the present results may be to prompt a reconsideration of current sodium reduction recommendations. Nature Publishing Group UK 2023-11-03 /pmc/articles/PMC10624927/ /pubmed/37923769 http://dx.doi.org/10.1038/s41598-023-46285-8 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Graudal, Niels Hubeck-Graudal, Thorbjørn Jurgens, Gesche A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
title | A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
title_full | A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
title_fullStr | A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
title_full_unstemmed | A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
title_short | A low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
title_sort | low dietary sodium dose is associated with a more pronounced aldosterone response in normotensive than in hypertensive individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624927/ https://www.ncbi.nlm.nih.gov/pubmed/37923769 http://dx.doi.org/10.1038/s41598-023-46285-8 |
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