Red Light‐Triggered Anti‐Angiogenic and Photodynamic Combination Therapy of Age‐Related Macular Degeneration (Adv. Sci. 31/2023)

Red Light‐Activated Combination Therapy of Eye Diseases In article number 2301985, Xiaoling Liang, Weiping Wang, and co‐workers report a red‐light‐triggered intraocular drug release strategy to achieve combination treatment of wet age‐related macular degeneration. Intravenous administration of a pho...

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Detalles Bibliográficos
Autores principales: Xu, Shuting, Cui, Kaixuan, Long, Kaiqi, Li, Jia, Fan, Ni, Lam, Wai‐Ching, Liang, Xiaoling, Wang, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625050/
http://dx.doi.org/10.1002/advs.202370211
Descripción
Sumario:Red Light‐Activated Combination Therapy of Eye Diseases In article number 2301985, Xiaoling Liang, Weiping Wang, and co‐workers report a red‐light‐triggered intraocular drug release strategy to achieve combination treatment of wet age‐related macular degeneration. Intravenous administration of a photoactivatable nanosystem followed by light irradiation to the diseased eye leads to intraocular release of an anti‐angiogenic agent, together with selective neo‐vessels occlusion by photodynamic therapy. This study provides a promising paradigm for minimally invasive administration of combination therapeutic agents for angiogenic eye diseases. [Image: see text]

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