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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023)
Lysosome In article number 2301120, Xiao‐Jiang Li, Sen Yan, Shihua Li, and their colleagues utilized a small intrabody peptide linked to lysosomes to effectively reduce mutant proteins, offering a novel approach for the treatment of neurodegenerative diseases. The cover image depicts a rocket, with...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625084/ http://dx.doi.org/10.1002/advs.202370210 |
| _version_ | 1785131053402292224 |
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| author | Li, Caijuan Lin, Yingqi Chen, Yizhi Song, Xichen Zheng, Xiao Li, Jiawei He, Jun Chen, Xiusheng Huang, Chunhui Wang, Wei Wu, Jianhao Wu, Jiaxi Gao, Jiale Tu, Zhuchi Li, Xiao‐Jiang Yan, Sen Li, Shihua |
| author_facet | Li, Caijuan Lin, Yingqi Chen, Yizhi Song, Xichen Zheng, Xiao Li, Jiawei He, Jun Chen, Xiusheng Huang, Chunhui Wang, Wei Wu, Jianhao Wu, Jiaxi Gao, Jiale Tu, Zhuchi Li, Xiao‐Jiang Yan, Sen Li, Shihua |
| author_sort | Li, Caijuan |
| collection | PubMed |
| description | Lysosome In article number 2301120, Xiao‐Jiang Li, Sen Yan, Shihua Li, and their colleagues utilized a small intrabody peptide linked to lysosomes to effectively reduce mutant proteins, offering a novel approach for the treatment of neurodegenerative diseases. The cover image depicts a rocket, with its head representing the signal being transported to the lysosome, and its tail representing a segment of the intrabody that can recognize the Huntington protein. The black hole symbolizes the lysosome, where the protein is degraded, while the galaxies in space symbolize neurons. The Huntington protein is transported to the black hole in space via the rocket, symbolizing the interconnectedness of life and the universe. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10625084 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106250842023-11-05 A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) Li, Caijuan Lin, Yingqi Chen, Yizhi Song, Xichen Zheng, Xiao Li, Jiawei He, Jun Chen, Xiusheng Huang, Chunhui Wang, Wei Wu, Jianhao Wu, Jiaxi Gao, Jiale Tu, Zhuchi Li, Xiao‐Jiang Yan, Sen Li, Shihua Adv Sci (Weinh) Cover Picture Lysosome In article number 2301120, Xiao‐Jiang Li, Sen Yan, Shihua Li, and their colleagues utilized a small intrabody peptide linked to lysosomes to effectively reduce mutant proteins, offering a novel approach for the treatment of neurodegenerative diseases. The cover image depicts a rocket, with its head representing the signal being transported to the lysosome, and its tail representing a segment of the intrabody that can recognize the Huntington protein. The black hole symbolizes the lysosome, where the protein is degraded, while the galaxies in space symbolize neurons. The Huntington protein is transported to the black hole in space via the rocket, symbolizing the interconnectedness of life and the universe. [Image: see text] John Wiley and Sons Inc. 2023-11-04 /pmc/articles/PMC10625084/ http://dx.doi.org/10.1002/advs.202370210 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Cover Picture Li, Caijuan Lin, Yingqi Chen, Yizhi Song, Xichen Zheng, Xiao Li, Jiawei He, Jun Chen, Xiusheng Huang, Chunhui Wang, Wei Wu, Jianhao Wu, Jiaxi Gao, Jiale Tu, Zhuchi Li, Xiao‐Jiang Yan, Sen Li, Shihua A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) |
| title | A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) |
| title_full | A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) |
| title_fullStr | A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) |
| title_full_unstemmed | A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) |
| title_short | A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023) |
| title_sort | specific mini‐intrabody mediates lysosome degradation of mutant huntingtin (adv. sci. 31/2023) |
| topic | Cover Picture |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625084/ http://dx.doi.org/10.1002/advs.202370210 |
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