CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic, high-grade, and relapsed RMS. New treatments are urgently needed, especially systemic therapies. Chimeric Antigen Receptor T cells (CAR Ts) are very effect...

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Detalles Bibliográficos
Autores principales: Timpanaro, Andrea, Piccand, Caroline, Dzhumashev, Dzhangar, Anton-Joseph, Stenija, Robbi, Andrea, Moser, Janine, Rössler, Jochen, Bernasconi, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625270/
https://www.ncbi.nlm.nih.gov/pubmed/37924157
http://dx.doi.org/10.1186/s13046-023-02838-3

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