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Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia

Cefepime, a commonly prescribed fourth-generation cephalosporin, is well-known for its broad-spectrum antibacterial activity. While adverse drug reactions associated with cefepime are well documented, thrombocytopenia as a rare complication has gained attention due to its potential severity. Symptom...

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Autores principales: Chowdhury, Tutul, Karki, Sailesh, Anitha Rajeev, Parvathy, Sajeev, Annmarie T, Aryal, Binit, Bellamkonda, Amulya, Basnet, Prava, Panigrahi, Kalpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625309/
https://www.ncbi.nlm.nih.gov/pubmed/37927729
http://dx.doi.org/10.7759/cureus.46518
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author Chowdhury, Tutul
Karki, Sailesh
Anitha Rajeev, Parvathy
Sajeev, Annmarie T
Aryal, Binit
Bellamkonda, Amulya
Basnet, Prava
Panigrahi, Kalpana
author_facet Chowdhury, Tutul
Karki, Sailesh
Anitha Rajeev, Parvathy
Sajeev, Annmarie T
Aryal, Binit
Bellamkonda, Amulya
Basnet, Prava
Panigrahi, Kalpana
author_sort Chowdhury, Tutul
collection PubMed
description Cefepime, a commonly prescribed fourth-generation cephalosporin, is well-known for its broad-spectrum antibacterial activity. While adverse drug reactions associated with cefepime are well documented, thrombocytopenia as a rare complication has gained attention due to its potential severity. Symptomatic patients present with purpura (bruising), petechiae (small red or purple spots on the skin), and mucosal bleeding. Drug-induced thrombocytopenia can be initiated by myelosuppression by halting platelet formation in the bone marrow or by a drug-induced immune thrombocytopenia reaction. We present a case of a 71-year-old male who experienced thrombocytopenia secondary to cefepime use. We further discussed the underlying mechanisms of cefepime-induced thrombocytopenia, highlighting the need for increased vigilance in monitoring platelet counts during cefepime administration. This case underscores the importance of recognizing and managing this uncommon but potentially life-threatening adverse reaction in clinical practice.
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spelling pubmed-106253092023-11-05 Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia Chowdhury, Tutul Karki, Sailesh Anitha Rajeev, Parvathy Sajeev, Annmarie T Aryal, Binit Bellamkonda, Amulya Basnet, Prava Panigrahi, Kalpana Cureus Internal Medicine Cefepime, a commonly prescribed fourth-generation cephalosporin, is well-known for its broad-spectrum antibacterial activity. While adverse drug reactions associated with cefepime are well documented, thrombocytopenia as a rare complication has gained attention due to its potential severity. Symptomatic patients present with purpura (bruising), petechiae (small red or purple spots on the skin), and mucosal bleeding. Drug-induced thrombocytopenia can be initiated by myelosuppression by halting platelet formation in the bone marrow or by a drug-induced immune thrombocytopenia reaction. We present a case of a 71-year-old male who experienced thrombocytopenia secondary to cefepime use. We further discussed the underlying mechanisms of cefepime-induced thrombocytopenia, highlighting the need for increased vigilance in monitoring platelet counts during cefepime administration. This case underscores the importance of recognizing and managing this uncommon but potentially life-threatening adverse reaction in clinical practice. Cureus 2023-10-05 /pmc/articles/PMC10625309/ /pubmed/37927729 http://dx.doi.org/10.7759/cureus.46518 Text en Copyright © 2023, Chowdhury et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Chowdhury, Tutul
Karki, Sailesh
Anitha Rajeev, Parvathy
Sajeev, Annmarie T
Aryal, Binit
Bellamkonda, Amulya
Basnet, Prava
Panigrahi, Kalpana
Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia
title Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia
title_full Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia
title_fullStr Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia
title_full_unstemmed Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia
title_short Unmasking the Silent Threat: Cefepime-Induced Thrombocytopenia
title_sort unmasking the silent threat: cefepime-induced thrombocytopenia
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625309/
https://www.ncbi.nlm.nih.gov/pubmed/37927729
http://dx.doi.org/10.7759/cureus.46518
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