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Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study
PURPOSE: Epigenetic age and inflammatory markers have been proposed as indicators of severity and mortality in patients with COVID-19. Furthermore, they have been associated with the occurrence of neurological symptoms, psychiatric manifestations, and cognitive impairment. Therefore, we aimed to exp...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625328/ https://www.ncbi.nlm.nih.gov/pubmed/37928957 http://dx.doi.org/10.2147/IJGM.S426249 |
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author | Nolasco-Rosales, Germán Alberto Alonso-García, Cecilia Yazmin Hernández-Martínez, David Gustavo Villar-Soto, Mario Martínez-Magaña, José J Genis-Mendoza, Alma Delia González-Castro, Thelma Beatriz Tovilla-Zarate, Carlos Alfonso Guzmán-Priego, Crystell Guadalupe Martínez-López, Mirian Carolina Nicolini, Humberto Juárez-Rojop, Isela Esther |
author_facet | Nolasco-Rosales, Germán Alberto Alonso-García, Cecilia Yazmin Hernández-Martínez, David Gustavo Villar-Soto, Mario Martínez-Magaña, José J Genis-Mendoza, Alma Delia González-Castro, Thelma Beatriz Tovilla-Zarate, Carlos Alfonso Guzmán-Priego, Crystell Guadalupe Martínez-López, Mirian Carolina Nicolini, Humberto Juárez-Rojop, Isela Esther |
author_sort | Nolasco-Rosales, Germán Alberto |
collection | PubMed |
description | PURPOSE: Epigenetic age and inflammatory markers have been proposed as indicators of severity and mortality in patients with COVID-19. Furthermore, they have been associated with the occurrence of neurological symptoms, psychiatric manifestations, and cognitive impairment. Therefore, we aimed to explore the possible associations between epigenetic age, neuropsychiatric manifestations and inflammatory markers (neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], monocyte-lymphocyte ratio [MLR], and systemic immune-inflammation index [SII]) in healthcare personnel with post-COVID condition. PATIENTS AND METHODS: We applied the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) tests to 51 Mexican healthcare workers with post-COVID-19 condition; we also estimated their epigenetic age using the PhenoAge calculator. RESULTS: The participants had a post-COVID condition that lasted a median of 14 months (range: 1–20). High NLR (>1.73) had association with mild cognitive impairment by MMSE (p=0.013). Likewise, high MLR (>0.24) were associated with language domain in MOCA (p=0.046). Low PLR (<103.9) was also related to delayed recall in MOCA (p=0.040). Regarding comorbidities, hypertension was associated with SII (p=0.007), overweight with PLR (p=0.047) and alcoholism was associated with MLR (p=0.043). Interestingly, we observed associations of low PLR (<103.9) and low SII (<1.35) levels with increased duration of post-COVID condition (p=0.027, p=0.031). Likewise, increases in PhenoAge were associated with high levels of SII (OR=1.11, p=0.049), PLR (OR=1.12, p=0.035) and MLR (OR=1.12, p=0.030). CONCLUSION: We observed neurocognitive changes related to inflammatory markers and increases in epigenetic age in healthcare personnel with post-COVID-19 condition. Future research is required to assess mental and physical health in individuals with post-COVID-19 symptoms. |
format | Online Article Text |
id | pubmed-10625328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-106253282023-11-05 Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study Nolasco-Rosales, Germán Alberto Alonso-García, Cecilia Yazmin Hernández-Martínez, David Gustavo Villar-Soto, Mario Martínez-Magaña, José J Genis-Mendoza, Alma Delia González-Castro, Thelma Beatriz Tovilla-Zarate, Carlos Alfonso Guzmán-Priego, Crystell Guadalupe Martínez-López, Mirian Carolina Nicolini, Humberto Juárez-Rojop, Isela Esther Int J Gen Med Original Research PURPOSE: Epigenetic age and inflammatory markers have been proposed as indicators of severity and mortality in patients with COVID-19. Furthermore, they have been associated with the occurrence of neurological symptoms, psychiatric manifestations, and cognitive impairment. Therefore, we aimed to explore the possible associations between epigenetic age, neuropsychiatric manifestations and inflammatory markers (neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], monocyte-lymphocyte ratio [MLR], and systemic immune-inflammation index [SII]) in healthcare personnel with post-COVID condition. PATIENTS AND METHODS: We applied the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) tests to 51 Mexican healthcare workers with post-COVID-19 condition; we also estimated their epigenetic age using the PhenoAge calculator. RESULTS: The participants had a post-COVID condition that lasted a median of 14 months (range: 1–20). High NLR (>1.73) had association with mild cognitive impairment by MMSE (p=0.013). Likewise, high MLR (>0.24) were associated with language domain in MOCA (p=0.046). Low PLR (<103.9) was also related to delayed recall in MOCA (p=0.040). Regarding comorbidities, hypertension was associated with SII (p=0.007), overweight with PLR (p=0.047) and alcoholism was associated with MLR (p=0.043). Interestingly, we observed associations of low PLR (<103.9) and low SII (<1.35) levels with increased duration of post-COVID condition (p=0.027, p=0.031). Likewise, increases in PhenoAge were associated with high levels of SII (OR=1.11, p=0.049), PLR (OR=1.12, p=0.035) and MLR (OR=1.12, p=0.030). CONCLUSION: We observed neurocognitive changes related to inflammatory markers and increases in epigenetic age in healthcare personnel with post-COVID-19 condition. Future research is required to assess mental and physical health in individuals with post-COVID-19 symptoms. Dove 2023-10-31 /pmc/articles/PMC10625328/ /pubmed/37928957 http://dx.doi.org/10.2147/IJGM.S426249 Text en © 2023 Nolasco-Rosales et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Nolasco-Rosales, Germán Alberto Alonso-García, Cecilia Yazmin Hernández-Martínez, David Gustavo Villar-Soto, Mario Martínez-Magaña, José J Genis-Mendoza, Alma Delia González-Castro, Thelma Beatriz Tovilla-Zarate, Carlos Alfonso Guzmán-Priego, Crystell Guadalupe Martínez-López, Mirian Carolina Nicolini, Humberto Juárez-Rojop, Isela Esther Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study |
title | Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study |
title_full | Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study |
title_fullStr | Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study |
title_full_unstemmed | Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study |
title_short | Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study |
title_sort | aftereffects in epigenetic age related to cognitive decline and inflammatory markers in healthcare personnel with post-covid-19: a cross-sectional study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625328/ https://www.ncbi.nlm.nih.gov/pubmed/37928957 http://dx.doi.org/10.2147/IJGM.S426249 |
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