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CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
BACKGROUND: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625331/ https://www.ncbi.nlm.nih.gov/pubmed/37927958 http://dx.doi.org/10.2147/JIR.S431212 |
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author | Liu, Yingli Si, Dan Bai, Pingping Zhu, Li Zhang, Lili Chen, Qi Qi, Yong |
author_facet | Liu, Yingli Si, Dan Bai, Pingping Zhu, Li Zhang, Lili Chen, Qi Qi, Yong |
author_sort | Liu, Yingli |
collection | PubMed |
description | BACKGROUND: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients. METHODS: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein–protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples. RESULTS: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01). CONCLUSION: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients. |
format | Online Article Text |
id | pubmed-10625331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-106253312023-11-05 CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients Liu, Yingli Si, Dan Bai, Pingping Zhu, Li Zhang, Lili Chen, Qi Qi, Yong J Inflamm Res Original Research BACKGROUND: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients. METHODS: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein–protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples. RESULTS: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01). CONCLUSION: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients. Dove 2023-10-31 /pmc/articles/PMC10625331/ /pubmed/37927958 http://dx.doi.org/10.2147/JIR.S431212 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Liu, Yingli Si, Dan Bai, Pingping Zhu, Li Zhang, Lili Chen, Qi Qi, Yong CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients |
title | CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients |
title_full | CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients |
title_fullStr | CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients |
title_full_unstemmed | CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients |
title_short | CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients |
title_sort | cxcl10 may be responsible for susceptibility to pulmonary embolism in covid-19 patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625331/ https://www.ncbi.nlm.nih.gov/pubmed/37927958 http://dx.doi.org/10.2147/JIR.S431212 |
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