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CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients

BACKGROUND: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis...

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Autores principales: Liu, Yingli, Si, Dan, Bai, Pingping, Zhu, Li, Zhang, Lili, Chen, Qi, Qi, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625331/
https://www.ncbi.nlm.nih.gov/pubmed/37927958
http://dx.doi.org/10.2147/JIR.S431212
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author Liu, Yingli
Si, Dan
Bai, Pingping
Zhu, Li
Zhang, Lili
Chen, Qi
Qi, Yong
author_facet Liu, Yingli
Si, Dan
Bai, Pingping
Zhu, Li
Zhang, Lili
Chen, Qi
Qi, Yong
author_sort Liu, Yingli
collection PubMed
description BACKGROUND: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients. METHODS: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein–protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples. RESULTS: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01). CONCLUSION: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients.
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spelling pubmed-106253312023-11-05 CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients Liu, Yingli Si, Dan Bai, Pingping Zhu, Li Zhang, Lili Chen, Qi Qi, Yong J Inflamm Res Original Research BACKGROUND: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients. METHODS: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein–protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples. RESULTS: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01). CONCLUSION: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients. Dove 2023-10-31 /pmc/articles/PMC10625331/ /pubmed/37927958 http://dx.doi.org/10.2147/JIR.S431212 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Liu, Yingli
Si, Dan
Bai, Pingping
Zhu, Li
Zhang, Lili
Chen, Qi
Qi, Yong
CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
title CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
title_full CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
title_fullStr CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
title_full_unstemmed CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
title_short CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
title_sort cxcl10 may be responsible for susceptibility to pulmonary embolism in covid-19 patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625331/
https://www.ncbi.nlm.nih.gov/pubmed/37927958
http://dx.doi.org/10.2147/JIR.S431212
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