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Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran

Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of Fars prov...

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Autores principales: Radfard, Majid, Hashemi, Hassan, Baghapour, Mohammad Ali, Samaei, Mohammad Reza, Yunesian, Masud, Soleimani, Hamed, Azhdarpoor, Abooalfazl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625539/
https://www.ncbi.nlm.nih.gov/pubmed/37925586
http://dx.doi.org/10.1038/s41598-023-46262-1
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author Radfard, Majid
Hashemi, Hassan
Baghapour, Mohammad Ali
Samaei, Mohammad Reza
Yunesian, Masud
Soleimani, Hamed
Azhdarpoor, Abooalfazl
author_facet Radfard, Majid
Hashemi, Hassan
Baghapour, Mohammad Ali
Samaei, Mohammad Reza
Yunesian, Masud
Soleimani, Hamed
Azhdarpoor, Abooalfazl
author_sort Radfard, Majid
collection PubMed
description Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of Fars province and evaluate the attributed burden of disease. Non-carcinogenic risk assessment was performed using the hazard quotient (HQ) method, while the carcinogenic risk assessment utilized the excess lifetime cancer risk approach. The burden of disease was evaluated in terms of years of life lost, years lived with disability, and disability-adjusted life years (DALY) for three specific cancers: skin, lung, and kidney cancer. The average drinking water concentrations of arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) were determined to be 0.72, 0.4, 1.10 and 0.72 μg/L, respectively. The total average HQ of heavy metals in drinking water in the study area were 0.127, 0.0047, 0.0009 and 0.0069, respectively. The average ILCRs of heavy metal in the entire country were in the following order: 1.15 × 10(−5) for As, 2.22 × 10(−7) for Cd and 3.41 × 10(−7) for Cr. The results also indicated that among the various counties analyzed, Fasa experiences the greatest burden of disease in terms of DALYs, with a value of 87.56, specifically attributed to cancers caused by exposure to arsenic. Generally, it can be said that the burden of disease is a critical aspect of public health that requires comprehensive understanding and effective intervention.
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spelling pubmed-106255392023-11-06 Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran Radfard, Majid Hashemi, Hassan Baghapour, Mohammad Ali Samaei, Mohammad Reza Yunesian, Masud Soleimani, Hamed Azhdarpoor, Abooalfazl Sci Rep Article Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of Fars province and evaluate the attributed burden of disease. Non-carcinogenic risk assessment was performed using the hazard quotient (HQ) method, while the carcinogenic risk assessment utilized the excess lifetime cancer risk approach. The burden of disease was evaluated in terms of years of life lost, years lived with disability, and disability-adjusted life years (DALY) for three specific cancers: skin, lung, and kidney cancer. The average drinking water concentrations of arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) were determined to be 0.72, 0.4, 1.10 and 0.72 μg/L, respectively. The total average HQ of heavy metals in drinking water in the study area were 0.127, 0.0047, 0.0009 and 0.0069, respectively. The average ILCRs of heavy metal in the entire country were in the following order: 1.15 × 10(−5) for As, 2.22 × 10(−7) for Cd and 3.41 × 10(−7) for Cr. The results also indicated that among the various counties analyzed, Fasa experiences the greatest burden of disease in terms of DALYs, with a value of 87.56, specifically attributed to cancers caused by exposure to arsenic. Generally, it can be said that the burden of disease is a critical aspect of public health that requires comprehensive understanding and effective intervention. Nature Publishing Group UK 2023-11-04 /pmc/articles/PMC10625539/ /pubmed/37925586 http://dx.doi.org/10.1038/s41598-023-46262-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Radfard, Majid
Hashemi, Hassan
Baghapour, Mohammad Ali
Samaei, Mohammad Reza
Yunesian, Masud
Soleimani, Hamed
Azhdarpoor, Abooalfazl
Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
title Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
title_full Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
title_fullStr Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
title_full_unstemmed Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
title_short Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
title_sort prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in fars province, iran
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625539/
https://www.ncbi.nlm.nih.gov/pubmed/37925586
http://dx.doi.org/10.1038/s41598-023-46262-1
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